In Vitro Biochemist/Biophysicist

Schrödinger seeks an In Vitro Biochemist/Biophysicist to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.
As a bench scientist in the in vitro biology team with the Schrödinger Therapeutics Group, you'll collaborate with scientists and drug developers who have experience with all common target classes and therapeutic areas. We're supported by over 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Several of our programs have achieved development candidates, including progression to the clinic and FDA approval. You can view our entire pipeline of wholly-owned programs and collaborations here .
Who will love this job:

• A self starter who has extensive experience with in vitro biology assay development and execution, plus an in depth knowledge of protein biochemistry, enzymology and biophysics
• A creative collaborator who can multi-task and collaborate effectively
• A results-oriented, self-motivated team player who's skilled at working in a multidisciplinary environment
• A dedicated scientist who's comfortable working across a number of disease areas and able to shift gears quickly to advance drug discovery research
• An excellent oral and written communicator who can accurately document scientific results according to best practices

What you will do:

• Ideate, design and execute biochemical, biophysical and cell biology experiments in support of drug discovery projects
• Transfer optimized in vitro assays to CRO partners
• Provide in vitro biology input to multiple program teams and help enable biochemical, biophysical and cell-based assay development for characterization and screening of NCEs
• Manage CRO relationships to support, guide and troubleshoot biochemical, biophysical and cell-based experiments
• Review, analyze and interpret in vitro data and troubleshoot issues related to drug discovery projects
• Update the in vitro biology and program teams on active programs regularly

What you should have:

• PhD in enzymology, biochemistry or a related field with 0-2 years relevant hands-on experience, or MS with at least five years of relevant experience in academia or industry
• Expertise in establishing and troubleshooting in vitro biochemical/biophysical assays with experience in multi-mode assay platforms
• Hands-on experience in running binding and functional assays for compound screening and MOA studies
• Background in managing in vitro biology experiments for multiple drug discovery programs
• Experience in Hit ID for drug targets in the undrugged space
• Working knowledge of data analysis and statistical softwares e.g. GraphPad Prism, KinTech explorer

We'd prefer to hire someone with:

• Experience in handling cell cultures, and establishing and troubleshooting cell-based assays (e.g., CTG/MTT, Western blot, CETSA, ELISA and FRET/BRET assays)
• Experience with biophysical methods such as SPR, ITC, and NanoDSF

Pay and perks:
Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.
Sound exciting? Apply today and join us!
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.