Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of eighteen programs initially focused on genetic diseases with a fast, direct path to treating patients or with a high unmet need because they cannot be treated using other gene-editing approaches. Over time, the Company intends to maximize Prime Editing’s therapeutic potential and advance potentially curative therapeutic options to patients for a broad spectrum of diseases. For more information, please visit www.primemedicine.com.
Position Overview:
We are currently seeking a talented and motivated Scientist I or II with expertise in HPLC and mass spectrometry to join the analytical development team in Prime’s Technical Development and Operations group. The candidate will play a key role in the application and development of a variety of HPLC, mass spectrometry (MS) and biophysical assays for the characterization of Prime editing components, drug substances and drug products across Prime’s portfolio, including long oligonucleotides (guide RNAs), conjugates, lipid nanoparticles (LNP), proteins, etc.
This is a hands-on role that provides an exciting opportunity to gain direct experience with all aspects of analytical development. The ideal candidate will excel as a member of a cross-functional team that works closely with the process development, formulation, chemistry, manufacturing, pharmacology, biology, and quality teams to advance the Prime Editing therapeutic product pipeline. The ideal candidate is an energetic learner, highly dependable, detail-oriented, multitasking bench scientist with demonstrated abilities for generating high-quality data in a multidisciplinary team setting.
Key Responsibilities:
- Assist with all aspects of analytical development, including new assay development, qualification and validation, and supporting routine sample analysis and stability testing.
- Contribute to new analytical method development to augment Prime’s analytical capabilities, including release, characterization, stability, and activity/potency assays.
- Conduct sample analysis for the characterization and release testing of Prime editing components, following experimental design, protocols, and standard operating procedures (SOP).
- Contribute to analytical sections in support of regulatory submissions.
- Assist in method transfer to CTLs (contract testing labs) and CDMOs (contract development and manufacturing organizations).
- Maintain electronic lab notebook following data integrity principles and practices.
- Effectively communicate results to multi-disciplinary teams in oral and written formats.
- Willingness to learn new skills and processes.
Qualifications:
- BS/MS/PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline.
- At least 5 years experience in the biotechnology or pharmaceutical industry for BS candidates, 3-6 years for MS and 0-3 years for PhD candidates.
- Experience with HPLC and/or LC-MS based analytical method development, qualification and/or validation.
- Experience with macromolecule analysis (proteins, antibodies, oligonucleotides, mRNA, etc.) is a plus.
- Capable of continuous improvement, learning new things, open-minded, curious, highly organized and detail-oriented.
- Strong collaborator with cross-functional teams.
- Ability to adapt quickly in a fast-paced environment with changing priorities.
- Highly self-motivated, driven, can-do, make it happen attitude.
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
Top Skills
What We Do
Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations.
We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.
