Scientist I, Analytical Development-NGS

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
 

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
 

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness

• ​Financial Wellness

• Support for Caregivers
   

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
 

The Importance of the Role

As a member of the Early Research Process Development – Analytical Development group this position will be responsible for the design and optimization of long-read DNA sequencing methods for evaluation of Adeno-Associated Virus (AAV). The individual must have hands-on experience in using next generation sequencing (NGS) platforms, data analysis, and method troubleshooting. The individual will collaborate with Early Research Process Development, Gene Therapy Research, and additional internal and external stakeholders to ensure the development and transfer of robust analytical methods.

The Opportunity to Make a Difference

• The successful candidate with be responsible for the following:
  • Design, optimization, and execution of NGS projects on the PacBio Vega sequencing platform including:
    • DNA extraction, isolation, and purification from AAV
    • DNA library preparation for long read sequencing
    • PacBio sequencer operation
    • Data quality monitoring
    • Data analysis and validation
    • In-depth understanding of principles and methods for sequencing analysis
  • Identifying and implementing operational improvements and novel technologies to solve analytical problems
  • Work seamlessly with cross-functional stakeholders
  • Participate in project related teams and other internal/external collaborations
  • Ensure that scientific and technical challenges are resolved in a timely manner
  • Maintain all appropriate laboratory records, author technical documents, protocols, and reports
  • Perform routine data analysis and visualization for use in presentations, publications, and internal reports
  • Contribute to a safe, efficient, and effective environment with personal accountability
  • Perform other related duties as required

More about You

• PhD Degree in Bioinformatics, Biostatistics, Biotechnology, Biochemistry, or related field
• 1-3+ years of related experience in method development and analysis in gene therapy and/or viral vector biology preferred
• Extensive hands-on experience with sequencing analysis tools and scripting/programming for bioinformatics (command line bioinformatics)
• Adaptable to the evolving field of bioinformatics
• Hands-on experience of NGS library preparation
• Experience working with liquid handling workstations
• Experience with Capillary Electrophoresis is desirable
• DNA/RNA quality control experience, e.g. TapeStation or equivalent, is desirable
• Ability to develop and troubleshoot methods with minimal supervision
• Excellent written and verbal communication skills
• Proven record of successfully planning experiments and executing projects in collaboration with internal or external stakeholders
• Proven ability to work independently and effectively handle multiple priorities is a must
• Ability to maintain confidentiality of proprietary information expected

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
 

#LI-Onsite

#LI-TG1

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $95,200 - $119,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.