PK/PD Principal Scientist

Role Description

The Zoetis pharmacokinetics, pharmacodynamics, metabolism group (PDM) is recruiting a talented scientist to join our team to discover and develop novel therapeutics for veterinary medicine. We are seeking a talented pharmacokinetics-pharmacodynamics scientist to join our research and development team. This position will require a highly motivated and independent leader who can effectively collaborate with other team members to advance projects. The successful candidate will be primarily responsible for designing, conducting, analyzing, and interpreting in vitro ADME and in vivo PK/PD studies in multiple species in support of projects from early research through late-stage development.

POSITION RESPONSIBILITIES:

• Independently design, conduct and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species.
• Design and interpret in vitro metabolism studies.
• Serve as study director or principal investigator for in vivo PK, PK/PD, TK, ADME, or clinical studies (GxP and non-GxP), including writing protocols and reports.
• Collaborate with bioanalytical team to forecast analytical requirements for projects and assess performance of analytical assays.
• Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
• Work collaboratively with multidisciplinary teams to prosecute studies and projects in line with the strategic direction of the team.
• Present research results to scientific teams, management, and regulatory agencies.
• Write sections of regulatory submissions, respond to inquiries from regulatory agencies, and maintain knowledge of regulatory guidance documents.

EDUCATION AND EXPERIENCE:

• Ph.D (1 – 10 years of relevant experience), in pharmaceutics, pharmacology, biochemistry, or related field.
• Ability to design, analyze and interpret in vivo PK and PK/PD studies.
• Design and interpret in vitro drug metabolism studies.
• Skilled in the use of PK and PK/PD analysis software such as WinNonlin or Watson. Experience in PK/PD modeling and simulation is highly desirable.
• Independent scientist with strong background in ADME.
• Solid background in statistics and experience with NOMEM, SAS, JMP and/or R is highly desirable.
• Excellent verbal/written communication, organizational and interpersonal skills.
• Self-starter, able to prioritize work and work efficiently with minimal supervision.
• Working knowledge of analytical methodology.
• Experience interacting with regulatory agencies is highly desirable.
• Experience conducting GLP studies is desirable

Full time

Regular

Colleague

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