GPCR Structural Biologist

Schrödinger is seeking a GPCR Structural Biologist to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods.
Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. We're supported by more than 100 software developers and engineers, as well as a large-scale computational infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved development candidates, including progression to clinical development and FDA approval. View our entire pipeline of wholly-owned programs and collaborations here .
This is a lab-based position in the Greater Boston area at our facility in Framingham, MA, which is fully equipped with protein production, biophysical characterization, and structure determination capabilities including a Thermo Scientific Glacios 2 Cryo-TEM with a Falcon 4i Direct Electron Detector and Selectris Imaging Filter.
Who will love this job:

• An expert gene-to-structure structural biologist who's eager to tackle challenging targets in drug discovery programs, with an emphasis on GPCRs
• A cryo-EM enthusiast with a proven track record of pushing the boundaries of sample preparation, data collection, and image analysis for the structure determination of small membrane proteins
• A team player who enjoys cross-functional collaboration
• A passionate scientist who's excited about utilizing protein structural information to enable structure- and computation-driven drug discovery programs

What you will do:

• Work in a state-of-the-art structural biology team of 20+ structural biologists, protein scientists, and biophysicists with fully integrated gene-to-structure capabilities
• Lead structural biology efforts by designing and executing experiments to support small-molecule drug discovery programs from target enablement through hit identification and later stages of the pipeline, with a primary focus on GPCR and other integral membrane protein targets
• Be an integral member of multidisciplinary drug discovery teams that leverage our computational platform to drive programs forward

What you should have:

• PhD in structural biology, biochemistry, biophysics, or a related discipline with 0-5 years of post-PhD experience
• Demonstrated success in prosecuting gene-to-structure campaigns for GPCR targets, including construct design, protein production, biochemical/biophysical characterization, and structure determination
• Deep knowledge of high-resolution structure determination of biological samples by cryo-EM, from sample vitrification to data collection and image analysis
• Experience with LCP crystallography and common biophysical techniques (e.g., SPR, MST, nanoDSF, mass photometry) preferred

Pay and perks:
Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.
Sound exciting? Apply today and join us!
As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.