Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position
Nurix is seeking a highly skilled and motivated Cloud Compute and Database Developer to join our dynamic Early Drug Discovery team, specifically within the Cheminformatics and Machine Learning department. This critical role will empower Nurix scientists to leverage our extensive DNA Encoded Library (DEL) and Degrader datasets, driving innovation in drug discovery. As a key member of the team, you will collaborate closely with a diverse group of scientists, informaticians, and engineers, contributing to the development and maintenance of cutting-edge infrastructure solutions. This includes designing, building, and optimizing high-performance computing (HPC) environments, scalable cloud-based data processing pipelines, and robust database systems. This position offers a unique opportunity to work at the intersection of biotechnology, machine learning, and high-performance computing, directly impacting the future of medicine.
Responsibilities
- Collaborate with research teams to design and implement data processing solutions and workflows tailored to bioinformatics needs.
- Manage high-performance computing (HPC) infrastructure, ensuring efficient automation and scalability.
- Develop interactive dashboard-style front ends for user interaction with backend systems.
- Design, build, and optimize database systems, complex queries, ETL pipelines, and reporting frameworks across informatics silos, ranging into terabyte scale.
- Maintain and improve existing web applications and backend systems in production to ensure reliability and performance.
- Provide mentorship and support to team members, fostering growth in problem-solving skills, development techniques, and best practices.
Required Skills
- Programming Languages: Python, JavaScript.
- AWS Services: Hands-on experience with AWS, especially EC2, S3, Batch, Athena, SageMaker, RDS, and EMR.
- Database Expertise: Advanced knowledge of SQL for complex queries and data management.
- DevOps: Docker, Linux, Anaconda, CI/CD pipelines.
- Python Libraries: pandas, boto3, awswrangler, matplotlib, streamlit, pyshiny, flask, fastapi.
Additional Useful Skills
- C/C++ and R
- Tibco Spotfire
- Windows
- Machine learning (ML) workflows and MLOps
- Apache Spark, Hive
- Experience working in a biotech and basic understanding of science
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).
Top Skills
What We Do
Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels.
Our drugs control ubiquitin E3 ligases, the key enzymes responsible for protein breakdown in human cells, as a unique therapeutic approach to treat a broad range of diseases.
Our focus is on developing drugs to treat cancer including novel, small molecule immuno-oncology agents
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