Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.
The Alumis team is seeking a highly motivated Contract Sr. Research Associate of Analytical Development to join our dynamic small molecule analytical group. The successful candidate will use their knowledge, experience, and skills to support analytical development activities to advance Alumis drug candidates through the clinical phases to commercial products.
RESPONSIBILITIES
- Under direct supervision, execute in-house analytical laboratory activities, such as analytical method development, sample analysis, and data reporting.
- Operate, maintain, and troubleshoot analytical laboratory instrumentation as needed to execute assigned laboratory experiments.
- Accurately document laboratory experiments and results in an electronic laboratory notebook.
- Support outsourced analytical testing activities as needed, such as analytical method development, method transfers and validations, sample and reference material management, and release and stability testing.
- Review CMO/CTL analytical data (in-process, release, and stability data) for accuracy and completeness, and effectively communicate data errors and gaps to supervisor.
THE IDEAL CANDIDATE
- BS or MS in chemistry or pharmaceutical sciences with minimum 3 years of experience in an analytical laboratory environment.
- Understanding of the basic principles of analytical method development, validations, and troubleshooting.
- Direct experience with small molecule analytical techniques used for clinical phase drug substances and drug products, such as UPLC/HPLC, LC-MS, GC, KF, UV/Vis, IR, particle size analysis, dissolution testing, DSC, TGA, and XRPD.
- Experience with reviewing GMP analytical data generated at CMOs and CTLs.
- Self-motivated and driven to complete assigned tasks in a timely manner to advance the project pipeline.
- Strong organizational, communication, and collaborative skills.
- Working knowledge of ICH, cGMP, and regulatory requirements for small molecule drug substances and drug products.
This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday.* At this time we are not considering remote applicants.
Contractor perks include:
- Free access to Genentech Bus & Ferry Share program
- Free onsite gym and a kitchen stocked with yummy snacks and drinks!
We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.
*Lab Personnel are generally onsite 4-5 days/week.
Top Skills
What We Do
At Alumis, our goal is to significantly improve the lives of patients by replacing broad immunosuppression with targeted therapies.
We recognize that patients living with immune-mediated diseases need alternatives to currently available therapies. Despite recent advances and innovations in the treatment of immune-mediated diseases, many patients continue to suffer, cycling through currently approved therapies while looking for a solution that alleviates the debilitating impact of their disease without life-limiting side effects.
Addressing the needs of these patients is why we exist. We are pioneering a precision approach that leverages insights we derive from powerful data analytics to select the right target, right molecule, right indication, right patient, and right endpoint resulting in optimized outcomes for patients. We believe that combining our insights with an integrated approach to drug development will produce the next generation of treatments to address immune dysfunction.
Incubated by Foresite Labs, Alumis is led by a team of deeply experienced professionals who are devoted to transforming the lives of patients with immune-mediated diseases by developing a pipeline of transformative therapies.
