Senti Bio is seeking a highly motivated and experienced Analytical Development Associate to support the buildout of Senti’s analytical platforms. The successful candidate will contribute to the advancement of Senti’s proprietary immunotherapeutic cell engineering platform focused on the development of key characterization and release assays. This role will mainly lead/support development and qualification of flow cytometry based assays with opportunities to support molecular and immunoassays as well. In parallel, building CMC data for IND filings. The candidate will work closely with the QC group providing training, writing documents, and supporting method transfers. The candidate will be expected to collaborate with multiple groups, independently perform experiments, analyze data and present results.
Responsibilities
- Supporting the development flow cytometry method, particularly QC release assays
- Creating and supporting the qualification of phenotype, purity, and expression panels
- Create CMC data for IND filings and support writing of method development sections
- Training of QC staff in preparation of tech transfer
- As needed support development of immunoassays, molecular, and cell-based methods
- Key contributor to researching, investigating, and implementing new technologies and methods
- Mentor and supervise junior Associates
- Independently perform experiments, organize and analyze results
- Successfully execute and document laboratory procedures and experiments with great attention to detail
- Maintain accurate lab records and notebooks
- Other duties as assigned
Qualifications
- Bachelor or master’s degree in Cell & Molecular Biology or related life science field
- A minimum of 5 years of relevant experience, analytical development industry experience is strongly preferred
- Strong experience in development of flow cytometry methods
- Experience with method qualification and transfer
- Experience with tissue culture (adherent and suspension)
- Experience with molecular and immuno-based methods (qPCR, dPCR, ELISA) is a plus
- Ability to multitask and meet deadlines in a fast-paced environment
- Ability to think critically and demonstrate troubleshooting and problem-solving skills
- Must be a team player, proactive and willing to work in a small team environment
- Must have excellent verbal and written communication skills
- Proficient with MS office and other commonly used software and technology platforms
- Self-motivated and eager to take on temporary responsibilities outside of initial job description
Salary and Benefits
- Compensation for this role includes base salary, annual target bonus and equity.
- The base salary range for this role is $46.00-$55.00 per hour. Starting pay is determined by multiple job-related factors including a candidate’s skills, education and experience level, benchmark, and internal parity.
- Significant growth opportunity as the company expands.
- Empathetic, supportive, and collaborative colleagues and work environments
Top Skills
What We Do
Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. To accomplish this mission, we are building a synthetic biology platform that could enable us to program next-generation cell and gene therapies with what we refer to as “gene circuits”. These gene circuits, which are created from novel and proprietary combinations of DNA sequences, are intended to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We are designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines do not readily address.
For more information, please visit the Senti Bio website at https://www.sentibio.com.
