Chief Scientific Officer (CSO) of Internal Medicine

ROLE SUMMARY
The Chief Scientific Officer (CSO) of Internal Medicine (IM) is based in Cambridge, MA, and reports to the Chief Internal Medicine Officer. The IM CSO will lead all drug discovery up to IND enabling studies to support first-in-human (FIH) dosing for Pfizer's Internal Medicine research programs. The IM CSO will develop and drive the strategy of the research unit to identify the best therapeutic targets and advance the most promising candidates that will build and deliver the unit's pipeline of new obesity and cardiometabolic medicines. The IM CSO is part of a team of leaders - working in close partnership with the Chief Internal Medicine Officer, the IM Chief Development Officer and the IM Commercial Lead. This leadership team is responsible for developing and implementing the end-to-end strategy for Pfizer's internal medicine portfolio from discovery through commercialization.
The IM CSO has direct line management responsibility for a team of approximately 100 colleagues with an operational budget of approximately $45M .
ROLE RESPONSIBILITIES

• Provide exceptional leadership for the development and execution of IM's scientific research.
• Deliver the IM portfolio to advance high quality, first in class candidates to first in human studies (FIH) to support the delivery of medicines that are medically differentiated and commercially viable.
• Partner with IM Chief Development Officer and IM Commercial Lead to develop and implement Pfizer's Internal Medicine strategy.
• Drive innovation and breaking science that will advance the best molecules and hypotheses ahead of the competition.
• Provide clear vision and scientific expertise while delegating hands-on execution against objectives within the organization.
• Lead IM research with significant capabilities in a highly matrixed environment.
• Connect emerging science, unmet medical need, and commercial viability to identify opportunities for drug development internally and externally.
• Advance all programs by the best means to test them quickly and convincingly in humans making scientifically sound decisions at each key milestone.
• Build scientific capability and expertise for current projects and for strategic areas of investment in the internal medicine area. Support the career development of colleagues at levels within the IM research unit.
• Partner continuously through robust dialogue with the commercial business to align end-to-end internal medicine therapeutic activities in-line with the overall strategic plan.
• Build and sustain a strong focus on value-based returns making tradeoffs between investment decisions and budgets in the delivery of differentiated medicines. ,
• Nurture an IM end-to-end culture which, (1) engages Pfizer colleagues both within the IM research teams and beyond to enthusiastically and optimistically strive for the discovery of new medicines addressing unmet medical needs; (2) actively seeks, embraces, and successfully applies the best biomedical research to discovering new drugs; and (3) doggedly aims to win the race with competitors to deliver the first and/or best-in-class therapies.

STRATEGY

• Develop and drive implementation of the IM research strategy/business plan and ensure close collaboration and alignment with Development, Regulatory, and Commercial leadership for the end-to-end Internal Medicine strategic plan.
• Provide exemplary scientific and strategic leadership in developing and growing drug discovery capabilities.
• Provide thought leadership, mentorship, operational excellence, and influence to create an environment of collaborative research that drives successful programs to meet the scientific and business objectives of the company.
• Set priorities within IM research as the single point of accountability for the delivery of discovery research and clinical candidates for the Internal Medicine area.
• Set objectives for the creation of value by the IMRU that realizes the end-to-end therapeutic area strategy and provides an appropriate return on investment.
• Influence the global external environment through thought leadership and visible, active engagement with key opinion leaders, regulatory authorities, payers, patient advocacy groups, and other key stakeholders.

P ORTFOLIO

• Ensure IM research has a sustainable, highly competitive pipeline from idea-to-FIH.
• Identify and build a network of external collaborators whose emerging science is most applicable to the objectives of the Internal Medicine R&D organization
• Ensure scientific strategy for each drug discovery project is optimal and cost effective by appropriate reviews with relevant experts inside and outside Pfizer's R&D organizations
• Govern current programs and candidates progressing through discovery to first-in-human (FIH).
• Interface with senior leaders for other therapeutic area units to ensure Pfizer's portfolio optimally balances risk with opportunity, and to exploit the full repertoire of therapeutic modalities.

MANAGEMENT

• Lead an engaged and dedicated workforce of ~100 scientists and life sciences professionals.
• Ensure all activities executed by IM research are delivered on budget and comply with all legal and regulatory requirements and with Pfizer corporate policies.
• Ensure the IM portfolio is adequately resourced to deliver value objectives; together with partner lines make cost effective resourcing decisions to ensure maximum value generation.
• Communicate IM research strategy and portfolio progress to key stakeholders across Pfizer
• Be the face of Internal Medicine research efforts to the global biomedical research community and to external advisors.

QUALIFICATIONS

• PhD, PharmD, and/or MD is required
• The ideal candidate will be highly respected and recognized within the scientific and biomedical community across academia and industry.
• S/He will have a passion for developing medicines and a proven track record of innovative discovery work, experimental medicine, and/or completion of positive POC activities.
• Prior management experience and the ability to lead through change will be sought.
• The IM CSO will be organizationally savvy and understand how to navigate a global organization and the external community.
• S/He is energized by the opportunity to lead through change and foster cohesiveness within a team.
• S/He enjoys communicating frequently with key internal stakeholders, as well as building new functions and capabilities.

PREFERRED QUALIFICATIONS
The successful candidate for this role will have also demonstrated the following critical competencies:

• Scientific Excellence : The successful candidate will be a world-class scientist and entrepreneur ideally with research experience and interests in one or more of cardiovascular, metabolic, and renal disease. Her/His key experiences should span activities from idea through POC. S/He will have a track record for key advances and discoveries in their respective field. S/He will have a deep understanding of biology, disease, and medicine in a relevant area of interest to the internal medicine group. S/He should have deep knowledge of the competitive landscape for one or more of the therapeutic disease areas within the scope of IM research.
• Team Leadership : The successful candidate will have strong leadership skills, including previous experience managing and motivating scientific teams. S/He has developed and led high-performance, matrixed teams with a thorough appreciation of each individual's capabilities, and then has structured work accordingly to obtain critical contributions. S/He should be able to build a culture of high performance, set expectations, hold team members accountable, and empower the team to solve problems and generate new ideas.
• Strategic Orientation : The ideal candidate will have strong strategic orientation as evidenced by good analytical and conceptual ability and a tendency to think beyond his/her own area. S/He should understand Pfizer's strategic objectives and develop a clear roadmap for pursuing research opportunities that align with that vision. S/He should be able to clearly articulate near- to long-term opportunities and threats, evaluate options and plans against anticipated trends, taking proactive steps to address them and support the overall R&D strategy. S/He will be a strategic thinker and a contributor of ideas and solutions who is able to leverage skills to shape thoughts and ideas from others and who uses informal structure, dynamics, and culture to get things done.
• Collaboration and Influencing : The successful candidate will proactively seek input in decision-making and show others how their own objectives align with his/her own and those of his/her team. S/He should have a proven track record of encouraging and overseeing multiple successful relationships across academic institutions and industry partners. S/He also motivates others to work with him/her, using the structure, dynamics, and culture of Pfizer and beyond to achieve organizational objectives. Proven track record to effectively collaborate with relevant therapeutic patient associations, advocacy groups, and foundations.
• Results Orientation : The successful candidate will be energized by a challenge, set new goals, and deliver beyond expectations. S/He should possess excellent judgment and decision-making capabilities. S/He will bring solid experience from best-in-class operations that can optimize the timeliness, cost effectiveness, and results of the initiatives, creating higher levels of performance by creating better ways of doing things. Ideally, s/he will break new ground to significantly improve the delivery of goals and set best-in-class standards.

OTHER INFORMATION

• This position is based in Cambridge, MA
• Relocation eligible

ORGANIZATIONAL RELATIONSHIPS

• President, Pfizer's Research and Development
• Chief Internal Medicine Officer
• Internal Medicine Leadership team
• Commercial leadership in the Internal Medicine area
• The IM Therapeutic Area Scientific Advisory Panel (TASAP), other external advisory boards (i.e., EAC) and scientific members of the Board of Directors comprised of leading researchers in the area from academia.
• External collaborators with academic institutions, institutes, patient advocacy groups and other strategic partners.

The annual base salary for this position ranges from $315,000.00 to $525,000.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 45.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development