cADME Senior Scientist

Posted 3 Days Ago
Be an Early Applicant
Groton, CT
Hybrid
91K-152K Annually
Mid level
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
We’re in relentless pursuit of breakthroughs that change patients’ lives.
The Role
As a Cheminformatics Data Scientist, you will develop data mining algorithms, analyze chemical datasets, and maintain AI/ML models to support drug discovery efforts.
Summary Generated by Built In

ROLE SUMMARY
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
Computational ADME
Cheminformatics Data Scientist
As the world's leading pharmaceutical company, Pfizer holds a unique position with some of the largest and most complex chemical and biological data sets globally. The computational absorption, distribution, metabolism, and excretion (cADME) group at Pfizer is responsible for maximizing the value of ADME, Safety, and Pharmacology data generated to support drug discovery project teams. As a Cheminformatics Data Scientist, you will leverage data-driven approaches to tackle drug discovery chemical and biological challenges. You will apply and develop machine learning models for molecular property prediction, analyze and optimize hit-to-lead and lead optimization strategies from our proprietary knowledge base, and collaborate closely with both internal and external partners to maximize the value of our industry-leading datasets.
Responsibilities:

  • Develop and apply cheminformatics data-mining algorithms for the analysis of molecular modeling, virtual screening, and structure-activity relationship (SAR) analysis.
  • Process and analyze chemical and biological datasets to evaluate properties such as drug-likeness, ADMET properties, dosing, etc.
  • Utilize molecular fingerprints, descriptors, and similarity metrics for compound clustering, classification, and regression.
  • Assist in development, maintenance, and monitoring of AI/ML models used for property prediction.
  • Optimize data pipelines for processing and storing chemical structures using cheminformatics toolkits (RDKit, OpenEye, etc.).
  • Collaborate with cross-functional teams to integrate computational approaches into curation and analysis workflows.
  • Maintain best practices in data integrity, reproducibility, and documentation of QSAR AI/ML models.


Required Qualifications:

  • Ph.D. with 0 years of experience or Master's degree with 2+ years of experience in Cheminformatics, Computational Chemistry, Bioinformatics, Data Science, or a related field.
  • Proficiency in Python, with experience in cheminformatics libraries and topics (RDKit, OpenEye, DeepChem, InChI, SMILES/SMARTS).
  • Experience working in a structured collaborative data and software development environment (git).
  • Experience using SAR model-building software such as SciKit-Learn, Torch, etc.
  • Strong understanding of basic statistical concepts and how to evaluate and track model performance.


Preferred Qualifications:

  • Experience using DAGs to define data pipelines, e.g. Luigi, Airflow, Dagster, Prefect, Kubeflow.
  • Experience working with relational (SQL) and NoSQL databases for chemical data management.
  • Experience working with MLOps tools such as MLFlow, Neptune, or SageMaker.


PHYSICAL/MENTAL REQUIREMENTS
Ability to perform mathematical calculations and ability to perform complex data analysis
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Some travel required
Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
#LI-PFE

Top Skills

Airflow
Dagster
Deepchem
Kubeflow
Luigi
Mlflow
Neptune
NoSQL
Openeye
Prefect
Python
Rdkit
Sagemaker
Scikit-Learn
SQL
Torch

What the Team is Saying

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Anna
Esteban
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The Company
HQ: New York, NY
121,990 Employees
Hybrid Workplace
Year Founded: 1848

What We Do

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Why Work With Us

We are the inventors, the problem solvers, the big thinkers — those who surmount any hurdle to deliver breakthrough medicines to the people who are counting on them the most.

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