Associate Scientist, Protein Analytical and Binding Characterization

Associate Scientist, Protein Analytical and Binding Characterization
Job summary:
PharmaEssentia Innovation Research Center (PIRC) is seeking an Associate Scientist to join our Biologics Platform team and contribute to the development of first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and antibody-drug-conjugates (ADCs), with a novel mechanism of actions. The successful candidate will be involved in antibody and protein analytical, binding, and pre-developability assessment efforts. They will collaborate with other project team members in designing, optimizing, and performing analytical and binding assessment of antibody and biotherapeutics. They will analyze the data, interpret the results, and effectively communicate the results to the project teams in support of the company’s discovery pipeline. This is a lab-based position and will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.
The Company:
It’s not often you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You’ll find that rare opportunity at PharmaEssentia. Join us, and let’s transform lives, together.
PharmaEssentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology, oncology and immunology, with one approved product and a diversifying pipeline. We believe in the potential to improve both health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking.
Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung.
Our new research center, PharmaEssentia Innovation Research Center (PIRC), will build upon our invention and discovery-based innovation efforts originally established in Taiwan that led to a transformative advancement for treating polycythemia vera (one of the myeloid proliferative neoplasms). At PIRC, we aim to expand our current expertise in related therapeutic areas and identify novel therapeutic approaches in early to mid-stage discovery and development. Data scientists will leverage artificial intelligence and machine learning to inform new target and indication selections. The company is also recruiting for talented scientists who have deep knowledge in immunology, translational science, bioinformatics and biologics platforms to develop novel drugs employing disease-driving biology, novel technology in protein engineering, antibody discovery and new modalities.
Summary of Key Responsibilities:

• Execution of protein analytical methodologies to assess purity, stability, non-specificity, and other biophysical and biochemical properties, employing a variety of analytical equipment such as SEC/RP-HPLC, CE-SDS, cIEF/IEX, DLS, and DSF.
• Performing protein labeling (e.g., biotinylation and fluorophore conjugation) to generate the reagents for biologics discovery campaigns and analysis.
• Pre-developability and stability assessment of Biologics lead candidates.
• Characterizing binding, kinetics, and epitope using BLI and SPR.
• Collaborate extensively with other members of PIRC for protocol development and execution of studies in the immunology and oncology therapeutic area.
• Entering and analyzing data and thorough documentation of work in the Company’s ELN system.
• Presentation of results in team meetings, other group settings.
• Working cross-functionally as part of internal multi-disciplinary project teams.

Essential Qualifications:

• B.S./M.S. in biology, biochemistry, or a related scientific discipline with 7-10 years industry experience.
• Hands-on experience in developing and optimizing biochemistry and HPLC-based analytical methods.
• Experience with LC-MS analytical methods such as intact mass analysis, peptide mapping, and PTMs identification, etc. is highly preferred.
• Ability to follow defined procedures and protocols, and strong diligence.
• Willingness to learn new research methods and a desire for continued learning and development.
• Excellent organization and record-keeping skills.
• Demonstrated accountability and responsibility for own work; and ability to work both independently and in a team setting.