In Vitro Pharmacology Scientist

About Us

Dianthus Therapeutics is a publicly traded, clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

About the Role

As the In Vitro Pharmacology Scientist, you play a key role in advancing our drug discovery programs by developing and implementing innovative in vitro pharmacology assays. These efforts will support the evaluation of the efficacy, mechanism of action, and safety of novel therapeutic candidates.

Reporting to the Principal, Translational Scientist, you will design, execute and analyze pharmacological experiments for complement therapies and other pipeline programs. This is a laboratory-focused role requiring your full-time presence at our Watertown laboratory.

This role offers a unique opportunity to contribute directly to the discovery and development of life-changing therapies, collaborate within a dynamic and innovative team focused on cutting-edge science, as well as working in a growing organization with high visibility and opportunities for professional growth. Knowledge of the complement system and its therapeutic implications is highly desirable. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. 

Key Responsibilities

• Establish strong scientific and technical initiatives and hands-on execution of in vitro assays to support identification, characterization and mechanism of action of lead candidates.
• Ability to design, execute, troubleshoot and interpret experiments independently.
• Contribute to data analysis, visualization, and interpretation of experimental findings.
• Read and interpret scientific literature pertaining to the biology and pathophysiology of therapeutic programs to propose innovative solutions to biological questions.
• Participates in projects and team meetings to provide updates and enable data-driven decisions.
• Maintain scientific documentation in laboratory notebooks and internal study reports.
• Work collaboratively and cross-functionally with internal and external teams to ensure project milestones are achieved within timelines.
• Collaborate with external CROs to expand internal capabilities in assay development and lead optimization.
• Lab management, sourcing and maintenance of laboratory reagents, inventory and shipping materials is required.

 Experience

• Bachelor’s Degree with 7 years, master’s degree with 4 years, or PhD with 1 years of experience preferably in molecular biology and/or antibody drug development.
• A solid background of assay development for biochemical and cellular assays to support preclinical discovery projects.
• Proficiency with standard cell and molecular biology techniques including plate-based assays (ELISA, MSD, etc.), cell-based assays, flow cytometry, immunofluorescence, immunoprecipitation, protein detection & quantification, western blots, qPCR, etc.
• Experience with immunological assays and handling human blood and sera.
• Experience with multi-color flow cytometry staining of cells or tissues, operating flow cytometers, and analyzing flow cytometry data.
• Strong motivation to quickly learn new skills, grow as a scientist and adapt to novel challenges.
• Team player with ability to effectively collaborate in a project-focused, fast-paced environment.
• Highly flexible, responsive, and accountable work ethic.
• Strong verbal and written communication skills with the ability to present results in small group settings.
• Proficiency in relevant software including GraphPad Prism, Flowjo and Microsoft Office suite (i.e., Word, PowerPoint, Excel, Outlook, SharePoint, etc.).