Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.
4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
Company Differentiators:
• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY
This role oversees 4DMT’s:
- IT endpoint infrastructure and enterprise end-user services
- IT infrastructure, including servers, cloud services, hardware systems, and applications
- Planning and implementation of comprehensive infrastructure solutions aligned with organizational needs
RESPONSIBILITIES:
Infrastructure Design & Management:
- Plan, design, develop, and implement scalable, secure, and user-focused IT solutions, including high-end workstations, desktops, laptops, and mobile devices (secure BYOD).
- Manage virtualization technologies (e.g., VDI/VM) to enable flexible work arrangements.
- Deploy and configure Windows, macOS, and Linux operating systems to ensure compatibility, performance, and compliance with security standards.
- Administer and support Active Directory environments, including Group Policy management, user accounts, and domain controller maintenance.
- Maintain and optimize Windows Server and Linux systems, ensuring high availability, security, and performance.
- Support Google Cloud Platform (GCP) infrastructure, including compute, storage, and networking services, while leveraging GCP tools for monitoring, security, and cost optimization.
- Implement and maintain system images, software packages, and productivity/business applications.
Automation & Optimization:
- Develop and manage automation scripts and workflows to optimize operations, enhance user experience, and increase efficiency.
- Build comprehensive automated infrastructure management solutions, including configuration management, monitoring, and analytics, to improve operational efficiency and reliability.
- Continuously identify opportunities for automation and process improvement, driving innovation and operational excellence.
System Monitoring & Troubleshooting:
- Proactively monitor system performance and ensure high availability, reliability, and scalability.
- Rapidly troubleshoot and resolve hardware, software, and system issues, including those related to Active Directory, Windows, Linux, and GCP environments.
Security & Compliance:
- Implement robust security measures, including encryption, access controls, and antivirus solutions.
- Ensure compliance with regulatory requirements (e.g., SOX, 21 CFR Part 11) and industry best practices.
- Develop and refine technical documentation, policies, and user guides to ensure informed decision-making and promote self-service support.
Collaboration & Support:
- Provide technical support to end users, resolving issues promptly and effectively.
- Collaborate with cross-functional IT teams to assess needs and integrate technology solutions.
- Foster strong relationships with stakeholders to align technology solutions with business goals.
Technology Evaluation:
- Evaluate emerging technologies and recommend solutions that align with business objectives and budget constraints.
- Stay current with industry trends to inform organizational decisions and future-proof solutions.
Other Responsibilities:
- Participate in audits as needed and ensure alignment with IT policies and standards.
- Perform other duties as assigned, adapting to the dynamic needs of the organization.
QUALIFICATIONS:
Education:
- B.S. in Computer Science or related field
Experience:
- 7+ years' experience as user-focus infrastructure engineer delivering solutions in highly regulated, complex and multi-vendor ecosystems with a strong preference for candidates having pharma or biotech industry expertise and a deep understanding of compliance-driven environments.
- 8+ years' experience managing desktop and server OS and application patching and application packaging using sophisticated management systems (e.g. Intune, System Center Configuration Manager)
- 7+ years' experience supporting Windows Enterprise customers in a large-scale (300+ node) environment.
- Strong hands-on experience with Active Directory, Windows, Linux, and Google Cloud Platform (GCP).
- 5+ years biopharmaceutical experience in fast-growing environment.
- Industry recognized technical level education & experience.
- Office environment with daily onsite presence required.
- Daily onsite presence in an office environment.
Skills
- Successful track record of infrastructure architecture and administration, execution, and delivery.
- Ability to multi-task in a fast-paced, dynamic environment.
- Experience working in a regulated networking environment (SOX and 21CFR11).
- Excellent organizational, communication and customer service skills with active-listening skills.
- Proven adaptability to shifting project schedules, priorities, and assignments; able to make effective decisions under pressure.
- Demonstrated problem-solver with the ability to cope under pressure and coordinate multiple activities in a dynamic, fast-paced team environment.
- Excellent written and documentation skills including proof reading and attention to detail.
- Hands-on experience with hardware and software troubleshooting, system imaging, and software deployment tools.
- Must be a self-driven, motivated IT professional with strong analytical and problem-solving skills, and ability to diagnose and resolve complex technical issues.
- Excellent communication and interpersonal skills, with the ability to work effectively in a team environment and interact with diverse stakeholders including executive management.
- Proactively identify opportunities for process improvements and automation to streamline end-user support services.
- Proficient in automation technologies, including Pipeline Pilot, MS Power Automate and additional scripting languages, with a strong ability to leverage scripting expertise to streamline processes, enhance efficiency, and drive operational excellence.
- Comprehensive expertise in operating systems (Windows, macOS, Linux), virtualization technologies (e.g., VMware, Citrix Virtual Apps and Desktops), and endpoint management solutions (e.g., Microsoft Intune, SCCM, Tanium), M365, Okta, Active Directory, etc.
- Proven ability to adapt to shifting priorities while maintaining attention to detail and delivering high-quality results.
Base salary compensation range: $126,000 - $178,000
Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.
Base salary compensation range:
Bay Area Range:
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
Top Skills
What We Do
4DMT is a clinical stage biopharma company inventing and developing innovative products to unlock the full potential of genetic medicine to treat large market and rare diseases. Our vector discovery platform Therapeutic Vector Evolution harnesses the power of directed evolution, a Nobel Prize-winning technology, with approximately one billion synthetic AAV capsid-derived sequences to invent customized and evolved vectors with improved therapeutic profiles compared to wild-type vectors. Our product design, development and manufacturing engine empowers us to efficiently create our valuable and diverse product pipeline. This combination of bold innovation and relentless execution gives 4DMT the capability to revolutionize genetic medicines and to strive for potential curative therapies. We have built a deep portfolio of genetic medicine product candidates, with five product candidates in clinical trials for seven patient populations.
We are taking genetic medicine to new heights and into new disease areas to overcome challenges not addressed by existing medicines. This incredible challenge drives our relentless and talented team. Our people are the essence of our inspiring, innovative and collaborative environment that encourages individual contributions and provides opportunities for career development. We seek the best in the industry who identify with our mission and our bold and innovative results-driven approach. Our 4 Guiding Principles drive the way we work together:
- Dare to Cure
- Break Boundaries
- Beyond Yourself
- Prepare & Executive Relentlessly
