Sr Director - Portfolio Management

Posted Yesterday
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Indianapolis, IN
147K-216K Annually
Senior level
Healthtech • Biotech • Pharmaceutical
The Role
The Sr. Director manages portfolio projects in Small Molecule development, ensuring strategic alignment and timely delivery while leading cross-functional teams.
Summary Generated by Built In

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Brand Description:

The Sr. Director Portfolio Management role is responsible for facilitating and managing the development and implementation of an integrated technical agenda for the portfolio of commercially manufactured Small Molecules and future synthetic modalities. The person in this position is responsible for influencing the organization around project selection and strategies for these molecules and ensures development of integrated technical agendas from late state development to enable faster delivery of significant technical agendas.

The Sr. Director leads cross functional manufacturing/quality peers and senior management teams for Small Molecule portfolio oversight. This individual will be responsible for facilitating overall Small Molecule Product Governance for Technical Agenda business process throughout the year (including Strategic and Business Planning activities). Key project management tools and techniques such as development and management of project scope, timeline management, development of a risk management plan including mitigation strategies and contingency plan, and stakeholder management (communication and reporting) will be employed.

This position will be responsible for leading and managing molecule projects/programs with significant risk and complexity to achieve critical business objectives.

The Sr. Director will be responsible for leading and/or contributing to non-molecule portfolio strategic/transformative efforts.

The person in this role has a CM&C and/or Manufacturing background and is expected to provide strategic decision-making leadership for cross functional teams and participate in process improvement activities in Manufacturing.

Key Objectives/Deliverables

  • Pursue a clear understanding of the business/process needs across Small Molecules and lead the development of Small Molecule and other new modalities strategic integrated technical agenda and objectives.
  • Be accountable for the development of business processes to identify, prioritize, scope, plan, communicate and escalate technical agenda projects and initiatives across small molecule portfolio.
  • Lead technical agenda identification, scope development, benefit analysis and project planning in partnership with SMDD, Kinsale, API-EM, DPEM, and PR01. Ensure strategy and priority context are understood by all technical agenda contributors and partners.
  • Manage project plans through their lifecycle, identifying key risk and contingencies, decision points, and criteria for moving forward. In addition, develop strategic and tactical recommendations in conjunction with partners for review at the appropriate governance forums.
  • Create and lead in an environment that encourages open discussion on issues to achieve a robust outcome on project decisions as well as anticipating and resolving strategic and tactical issues that could impact the delivery of technical agenda projects and constructively challenge the team to reach the best solutions. Build and maintain effective teams; motivate, recognize, coach and mentor team members and associates.
  • Effectively manage upward and cross-functional communications, particularly with the members of the Business Unit, key manufacturing functions, and senior manufacturing/quality management.
  • Lead the Small Molecule Technical Agenda Hub (SMTAH) in tactical oversight of the technical agenda, including integration of technical projects, regulatory, and supply chain activities. Lead team in evaluation of integration impact due to new projects entering the portfolio and project milestone delays for existing projects. Ensure escalation and effective communication of project management issues, risks, and integration recommendations.
  • Proactively monitor emerging technical, regulatory, and supply chain environment issues and develop scenarios for addressing risks.
  • Influence internal and external customers/partners to identify opportunities for improving technologies, processes, and products.
  • Accountable for on time and within scope delivery of project milestones through the development of integrated project timelines; actively tracking leading indicators or team’s progress to major milestones.
  • Evaluate new requests for manufacturing or product changes. Drive development of draft operational plans for proposed new projects and ensures that data are available to allow evaluation of new projects.
  • Manage implementation of projects to ensure alignment with Business Unit, Regulatory, and Supply Chain partners. Ensure alignment and integration of team activities with quality assurance, quality control and drive efficient project and submission plans. Manage external partnership with research and manufacturing organizations as necessary.
  • Serve as network liaison for GPLOT technical agendas and/or network forums.
  • Responsible for leading and/or contributing to non-molecule TSMS PM strategic/transformative efforts:
    • Build TSMS Project Management capabilities and competencies
    • Define and optimize processes and standards which enable project/portfolio reporting and are integrated with M&Q stakeholders
    • Proactively identify areas for continuous improvement and simplification of PM tools, processes, and standards to address current and future needs (e.g., ARS)
  • Mentor project management (PM) consultants. Share learnings at PM staff meetings.

Basic Requirements:

  • BS, BA or MS in Chemistry, Biology, Pharmacy, Engineering or equivalent scientific degree
  • Experience with and the knowledge of the CMC aspects of drug development and manufacturing (pharmaceutical manufacturing experience required)
  • 10+ years of experience in more than one functional area within a manufacturing site (e.g., Operations, TS/MS, QA, QC, Regulatory, Engineering, or Supply Chain)
  • 3+ years prior project management experience with demonstrated knowledge of project management tool and processes
  • Prior demonstration of portfolio management

Additional Preferences:

  • Demonstrated successful leadership of cross-functional teams
  • Strong interpersonal and teamwork skills
  • Strong self-management and organizational skills
  • Strong problem-solving skills. Champion simplification and continuous improvement
  • Oral and written communication skills that demonstrate an ability to effectively (clearly, succinctly) communicate with all levels of the organization
  • Master’s in Project Management, PMP certification, or MBA
  • Six Sigma training and certification
  • Ability to lead transformational change
  • Demonstrated ability to lead and influence cross functionally including senior leadership
  • Consistent demonstration of the performance management leadership behaviors (e.g., model the values, create external focus)

Other Information:  Some travel (5%, domestic and international) may be required

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$147,000 - $215,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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The Company
HQ: Indianapolis, IN
39,451 Employees
On-site Workplace
Year Founded: 1876

What We Do

Eli Lilly and Company engages in the discovery, development, manufacture, and sale of products in pharmaceutical products business segment.

For more than a century, we have stayed true to a core set of values – excellence, integrity, and respect for people – that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.

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