Senior/Staff Engineer, Application

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you:

Glyphic is seeking an experienced applications engineer to translate our cutting-edge single molecule proteome sequencing protocols to automated instrumentation. The ideal candidate will have extensive experience developing complex assays on the Hamilton Star liquid handling platform for DNA & protein biochemistry and/or NGS applications. The engineer will work with a cross-disciplinary team of chemists, biologists, engineers, and bio-informaticians to deploy robust production processes across a range of laboratory automation and custom microfluidic instruments.

Responsibilities:

• Design, develop, deploy, and rapidly improve automated protein sequencing solutions in a fast-paced startup environment.

• Evaluate new instrumentation fit for purpose and integrate new automated capabilities into existing platform

• Partner with R&D to translate existing benchtop protocols and new protocol concepts across multiple platforms to demonstrate feasibility

• Define standardized liquid handler programming schema for rapid protocol, labware, and liquid class reusability 

• Utilize scheduling software to integrate multiple instruments and optimize automated protocols for throughput

• Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development.

• Maintain expertise on alternate methods, techniques and best practices used in the field; routinely benchmark process performance

• Thoroughly document the development lifecycle:

  • User requirements and instrument selection

  • IQ/OQ/PQ 

  • Operator SOPs and training materials

  • Instrument docs and maintenance procedures

Required Competencies:

• Degree in bioengineering, biology, chemistry, or related field, PhD preferred

• 6+ years hands-on industry experience with liquid handlers and lab automation

• Extensive experience developing assays on Hamilton Microlab Star / Venus

• Experience troubleshooting complex instrument/assay issues, performing root cause analysis, and driving corrective actions in a production environment

• Experience quantifying and qualifying your work through IQ/OQ/PQ

• Experience with laboratory information management systems

• Advanced programming and data modeling/analysis skills (Python, C++, vendor platforms)

Preferred:

• Experience with protein-based assays, nucleic acids biochemistry, and bioconjugation

• Experience developing and deploying methods in a regulated environment (GxP/CLIA/CAP/ISO)

• Experience with instrument integrations and scheduling software

• Experience developing of a commercial product

Benefits and Perks:

• Employee Stock Option Plan

• 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)

• Employer Retirement Contributions to 401(k)

• Generous Paid Time Off

• Paid Maternity and Paternity Leave

• Health & Wellbeing Program

• Office Snacks and Beverages

• Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.