Company Overview:
Beam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
We are seeking a Senior/Principal Research Associate to join our Analytical Research and Development group to support robustness testing, characterization, optimization and automation for current Beam programs. The ideal candidate will be self-motivated, technically competent, and responsible for performing/supporting assay optimizations, qualifications, and validations of product release and product characterization assays. The successful applicant will have a strong scientific background and desire to learn cell therapy, immunotherapy, and analytical method development.
Responsibilities:
- Support the development, design, and executing experiments for process/product characterization testing
- Perform method robustness testing for mRNA, gRNA, DP methods for validation readiness
- Support Beam’s early phase method development and optimization
- Perform various automated routine sample testing
- Help with routine assay transfer, troubleshooting and improvements
- Record highly detailed documentation of experiments in an ELN system
Qualifications
- BS/MS in Life Sciences, Immunology, Chemistry, or related discipline with 6+ years of relevant experience
- Strong background with molecular and cell-based assays
- Experience in maintaining a laboratory notebook and following protocols
- Desire and drive to learn and understand the basic biological mechanisms underpinning our cell and gene therapy products
- Team player with excellent oral and written communication skills
- Independently motivated, detail-oriented, and excellent problem-solving abilities
- Excellent organizational skills towards multi-tasking in an extremely fast-paced environment with changing priorities
- Experience with data analysis using JMP, python or R is a plus
- Experience with authoring SOPs, method qualification and technology transfer preferred
Top Skills
What We Do
Beam Therapeutics, launched in 2018, is pioneering the use of CRISPR base editing to develop a broad portfolio of advanced genetic medicines. Our groundbreaking base editing technology allows us to make permanent, specific edits to single bases in DNA and RNA, without cutting the strands. Base editor therapeutics represent a new class of “precision genetic medicines,” combining precision targeting of the genome with precision control of editing outcomes.
Our dream is to provide life-long cures for patients suffering from serious diseases.
The Beam Team Is:
• A community of fearless innovators
• Rigorous and honest in our research
• Listening with open minds
• Committed to each other
