Position Summary
Cellares is seeking an experienced and highly motivated Senior Systems Integration Engineer with expertise in complex instrumentation systems to join the Research and Development team. This individual will interface across many parts of the company and contribute significantly to the development of the advanced cell therapy systems that have never been realized before.
The ideal candidate will have a demonstrated experience in biomedical related instruments and consumables development/integration testing activities. As a Systems Integration Engineer, you are expected to learn and adapt to new technologies readily and take ownership of a wide range of tasks, and successfully drive the tasks to its completion. During the process, you will be required to provide in-depth analysis and help guide important decisions for troubleshooting and continuous improvement projects.
The successful candidate will show proven ability to work and communicate effectively with cross-functional teams, and extremely hands-on capability in prior working experiences.
Candidates should enjoy working in a fast-paced, mission-driven environment, and be prepared to tackle a broad selection of challenges as the company grows.
Responsibilities
- On-site technical lead to perform hands-on system characterization, integration, verification testing, troubleshooting, root-cause investigation and continuous improvement of Cellares technology platforms
- Work closely to Hardware, Software, Firmware and Process teams to perform system bring-up and regression testing for system improvement and feature upgrades
- Design, and execute complex experiments follow scientific principles and statistical approaches (DOE) to support development and characterization efforts
- Author and present quality technical documents, procedures, reports
- Produce technical training documentation and provide training and assistance for the operation team
- Work closely and interface with cross-functional teams to drive tasks to completion
Requirements
- BS in Engineering, Bioengineering, Physics, or related field with 6-11+ years of extensive, hands-on experience in the development of analytical instrumentation, biotech automation, or similar is required
- OR MS in Engineering, Bioengineering, Physics, or related field with 5-10+ years of experience
- OR PhD in Engineering, Bioengineering, Physics, or related field with 2+ years of extensive, hands-on experience in the development of analytical instrumentation, biotech automation, or similar is desirable
- Extensive hands-on experience in integration testing and troubleshooting in highly complex instrumentation systems that combine fluidic handling, electronic sensors, gas mixing and robotics
- Strong analytical and problem-solving skills
- Ability to effectively communicate technical concepts and details to non-engineers
- Interest in cell and cancer therapeutics required
- Hands-on experience with both autologous and allogeneic cell therapy manufacturing processes is a plus
- Experience with scripting languages (MATLAB, Python, JMP etc) for modeling, simulation and data processing
- Prior experience with ISO regulations, cGMP, QMS, IEC 61010 standards is preferred
- Excellent verbal, written, presentation and interpersonal skills
- Demonstrated track record of rapidly climbing steep learning curves.ils
- Creative, self-motivated, flexible to work in a rapidly evolving organization and assume a wide variety of tasks
- Self-awareness, integrity, authenticity, and a growth mindset
Top Skills
What We Do
Cellares is revolutionizing cell therapy manufacturing. We are developing a one-of-a-kind solution, The Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are affordable and widely available to patients who can benefit.
The clinical impact of cell therapy in treating cancer has been proven, but this therapeutic approach has several limitations, especially in manufacturing, leaving extremely sick patients waiting for treatment and desperate for hope.
Since cell therapy is currently produced for a single patient at a time, it is expensive to manufacture, requiring significant time and resources, and is difficult to scale.
Preclinical and clinical scientists, as well as commercial cell therapy manufacturers also lack the options to fully automate their manufacturing process quickly, safely, cost-effectively and at the scale they need.
The Cell Shuttle is an automated and closed end-to-end manufacturing solution that is flexible and scalable, enabling customers to run exact processes specified for their cell therapy. Compared with the current manual manufacturing processes for cell therapy, the Cell Shuttle’s next-generation automated manufacturing solution has 10 times the scalability (meaning 10 times more patient doses can be produced simultaneously), enables a three-fold reduction in process failure rates and will reduce the per-patient manufacturing cost by up to 70 percent for most processes.
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