Variant Bio is a Seattle-based biotechnology company leveraging the power of human genetic diversity to develop life-saving therapies. To achieve this goal, we are studying the genes of people who are outliers for medically relevant traits, then translating insights from this research into the discovery and development of new therapeutics.
Variant Bio has raised $130mm to support the rapid advancement of the company’s research and development work. Our investors include Lux Capital, Alta Partners, General Catalyst, SoftBank Vision Fund, Cercano Management and Casdin Capital, among others. Our growing team of geneticists, medical researchers, biologists, and drug hunters is working to advance multiple projects through target validation, lead optimization, and into the clinic, in relentless pursuit of our goal to bring life-saving therapies to patients.
Ethics is at the foundation of everything we do at Variant Bio. Our genomic research studies are co-designed with local partners around the world. In addition, we are committed to sharing tangible benefits with research partners and communities through our unique Benefit-sharing Program and Affordable Medicines Pledge.
Variant Bio is an equal opportunity employer that guarantees a work environment that respects and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status.
Job Description
The Genomic Discovery team is seeking a statistical geneticist with expertise in conducting analyses to advance drug discovery. The ideal candidate will have a strong foundation in statistical genetics methods and their applications. The candidate should also have experience applying best practices in statistical genetics and implementing rigorous quality control measures. In this role, they will design, execute, and interpret genetic analyses across diverse populations, leveraging insights to drive target identification and validation. We encourage candidates who are passionate about increasing the inclusion of underrepresented populations in genomic research to apply, as this is a core mission of Variant Bio. It is strongly preferred that this role is based in Seattle, WA and in the office a minimum of 3 days a week.
Responsibilities
- Utilize standard and custom statistical genetics software, including tools for genome-wide association studies and meta-analyses, to conduct analyses.
- Design and implement statistical genetic analyses across a variety of study designs including quantitative traits and family studies.
- Interpret results and refine follow-up analyses to ensure proper inference and support downstream applications.
- Familiar with post-GWAS analysis methods such as colocalization, conditional analysis, fine-mapping and mendelian randomization.
- Work with bioinformaticians, software engineers and cloud architects to mature workflows and integrate approaches into existing infrastructure.
- Communicate results internally and externally through presentations and publications.
Qualifications
- Ph.D. with 4+ years of experience, 10+ years with Masters in statistical genetics, genetic epidemiology or related field.
- Experience using genetics in drug discovery activities.
- Solid conceptual background in the key principles of population and statistical genetics, as well as formal training in statistics or genetic epidemiology.
- Good working knowledge of public human genomic resources, such as the 1000 Genomes Project, the Human Genome Diversity Project, gnomAD, the UK Biobank and other biobanks.
- Strong programming skills and experience with high performance computing.
- Independent, creative, detail-orientated, and a critical thinker.
- Compelled by the company’s mission of great science, a strong ethical stance, and benefit sharing.
What We Offer
- Opportunity to be part of a well funded and highly innovative biotech.
- Competitive, industry leading salary, and comprehensive benefits including medical, dental, vision, short and long term disability and life insurance.
- 401(k) plan through Fidelity that includes up to 3% employer match and flexible investment options.
- Flexible paid time off.
- Choice of public transportation (Orca Card) provided by the company or subsidized parking.
- Centrally located Eastlake, Seattle location in a new Alexandria building with modern facilities.
Anticipated annual base salary for this position is $150,000 - $185,000 plus up to 15% bonus and an options package, for total compensation of up to $172,500 - $212,750, plus equity options.
The annual salary range above is based on the responsibilities and qualifications listed above. Individual salary will depend on job-related knowledge, skills, and experience.
Don't meet every single requirement but are excited to join the Variant Bio team? If your past experience doesn't align perfectly with every qualification in the job description, we encourage you to apply anyway. You may still be the right candidate for this or other roles.
Top Skills
What We Do
Variant Bio is leveraging the power of human genetic diversity to discover new therapeutics.
Why Work With Us
Our team has a passion for exploration, and expertise spanning genetics, molecular biology, therapeutics, anthropology, and ethics. We started Variant Bio because we share the belief that human genomics has the power to transform drug development.
