Senior Scientist (Molecular Discovery)

Why Patients Need You
Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.
What You Will Achieve
Pfizer Worldwide Research and Development, La Jolla, CA, has an open position at the Senior Scientist level for a highly motivated and talented research scientist in the Structural Biology and Protein Sciences (SBPS) Group within the Department of Oncology Medicinal Chemistry. The SBPS mission is focused on enabling oncology drug discovery programs with protein tools, structure, function, and dynamic information. The position will primarily support the antibody-drug conjugate (ADC) portfolio with opportunity to also contribute broadly to small molecule focused programs.
How You Will Achieve It
As part of a gene-to-structure team within SBPS, the successful candidate will carry out, as needed, a full range of gene-to-structure and protein sciences experiments (including construct design, protein engineering, expression, purification, biophysical characterization, and structure determination by crystallography and cryo-electron microscopy) to advance multiple ADC drug discovery projects and science objectives in parallel.
The successful candidate will collaborate and interact with colleagues across the SBPS group and Medicinal Chemistry and Computational Chemistry groups in Bothell, WA, and La Jolla, CA, and will be an SBPS discipline resource in multi-disciplinary drug discovery team settings, contributing to robust and timely team problem solving and decision making. Occasional travel to Pfizer Bothell, WA is required.
Qualifications
Must-Have

• Ph.D. (or equivalent) in biochemistry, structural biology, or a related field.
• Extensive experience in protein biochemistry focused on exceptionally challenging biological systems, including construct design, expression (in multiple expression systems), protein purification, and biophysical characterizations.
• Extensive experience in all aspects of single particle cryo-electron microscopy, including grid preparation, data collection and data processing with proficiency in state-of-the-art software packages for cryo-electron microscopy, molecular modeling, and analysis.
• Hands-on experience in structure determination by X-ray crystallography, including crystallization/small molecule co-crystallization, model building, and refinement.
• Demonstrated scientific leadership to independently design, implement, and drive successful outcomes in gene-to-structure experimental strategies and experiments.
• Outstanding publication record reflecting scientific drive, productivity, and creativity across all disciplines of modern structural biology and protein sciences.
• Must be able to thrive and deliver results on goals in a fast paced, dynamic, and highly multi-tasking environment.
• Must be self-motivated and work well independently in an inclusive manner.
• Excellent communication and presentation skills that positively contribute to an environment where high value is placed on enabling and engaging teammates in robust science, scientific dialog, partnership, and teamwork.

Nice-to-Have

• Postdoctoral and/or industry experience
• Expertise in ADC technologies, including tumor associated antigen biology and internalization mechanisms.
• Experience in the use of ML/AI based approaches for structural biology, including protein engineering, construct design, and cryo-electron microscopy data processing.
• Experience in sample preparation, data collection, and processing of cryo-electron microscopy for helical samples or cryo-electron tomography.
• Broad understanding of biochemical assays, chemical biology, mechanistic enzymology, pharmacology.

Other Job Details:

• Last Date to Apply for Job: 04 SEPTEMBER 2024
• Eligible for Employee Referral Bonus
• Eligible for Relocation Assistance

Work Location Assignment: On Premise
On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.
The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development