Senior Scientist I, Pharmacology

How will your role help us transform hope into reality?

The Senior Scientist, Pharmacology will lead efforts within discovery projects to develop and implement in-vivo pharmacology strategies that contribute to demonstration of proof of concept and inform the identification, selection, and characterization of drug candidates. You will be accountable for the characterization of all aspects of in-vivo pharmacology in rodent and (when appropriate) higher species models of disease. You will serve as the Pharmacology representative on discovery core teams and will be expected to collaborate closely with partner functions (e.g. Biology, Medicinal Chemistry, Laboratory Animal Resources, Pharmaceutical Sciences, Translational Medicine, DMPK, Drug Safety) to impact experiment/study design and facilitate line of sight from Discovery to IND. This opportunity is highly collaborative, team-facing, and strategic, and you will also be responsible for designing and performing hands-on in-vivo studies conducted in the internal vivarium[RR1] . The successful applicant will be an outstanding scientist capable of independently leading in-vivo research efforts whether in-house or outsourced, and supporting collaborations with KOLs in specific areas of interest to the company.

What will you do?

• Provide pharmacology expertise to discovery programs: design, perform, interpret in vivo pharmacology studies to evaluate the activities of small molecule drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses
• Work seamlessly with discovery teams, the head of Laboratory Animal Resources, and the In Vivo Pharmacology Team to plan, perform, resource, and prioritize in-house and outsourced pharmacology activities
• Manage and perform hands-on in vivo pharmacology research in-house in a matrixed environment, as well as support studies being performed through an extensive network of CROs
• Perform ex vivo cell and tissue work, including but not limited to flow cytometry, ELISA, western blot, and quantitative RT-PCR
• Regularly analyze, document, and report in vivo and ex vivo data
• Regularly participate in project team meetings and present in vivo pharmacology results
• Manage in vivo pharmacology studies being performed at CROs
• Think strategically about drug development and drive innovative solutions to key challenges across the organization
• Responsible for In Vivo Pharmacology contributions to INDs , including preparation of nonclinical study reports
• Perform other responsibilities as assigned

What minimum qualifications do we require?

• PhD in pharmacology, biology, immunology or related discipline with 4+ years of additional industry experience in in-vivo pharmacology or a MS degree with 8+ years of demonstrated ability leading in-vivo pharmacology projects

What additional qualifications will make you a stronger candidate?

• Strong foundation in pharmacological principles
• Hands-on experience designing and performing in-vivo disease models in rodents, including tumor models or inflammatory disease models to assess efficacy and PK/PD is essential
• Hands-on experience with various routes of administration in rodents is essential
• Hands-on experience with rodent tissue collection and ex vivo processing techniques
• Experience in determining PK/PD to activity relationships in vivo in diseased and surrogate tissues
• Strong attention to detail and exceptional interpersonal, organizational, and communication skills
• Demonstrated ability to successfully influence internal and external cross-functional teams by exhibiting creative problem solving, clear decision-making, and accountability
• Experience with drug modalities beyond small molecules.
• Experience leading pharmacology aspects of projects at all stages of discovery and experience with preparation of nonclinical study reports is a plus
• Prior experience performing and interpreting in vivo/ex vivo immunological assays,
• Hands-on experience with multiparameter flow cytometry
• Ability to work effectively with project leads and project teams that have diverse personalities and styles
• Ability to lead effectively in a matrixed drug discovery environment
• Experience identifying, selecting, and overseeing the work of external CROs, consultants and partners
• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to [email protected]. 

For more information, please see our EEO-AA Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or the EEO Know Your Rights Poster, as well as our Pay Transparency Statement. 

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

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