Genesis Therapeutics is a leader in AI guided rational drug design with the goal to address unmet medical needs in various indications, including oncology and immunology.
Our San Diego lab is recruiting a Senior Research Associate/Scientist with experience in cellular and molecular immunology, assay development, cell biology and/or biochemistry, with a proven interest in addressing inflammatory and autoimmune diseases.
More specifically, we are seeking a candidate to execute SAR driving workflows while in parallel supporting mechanistic studies that advance multiple targets through preclinical development. This is a hands-on, lab-based position that requires close collaboration with colleagues across multiple functions.
Educational requirements consist of an advanced degree (BS, MS, or PhD) in a relevant field, complemented by industry experience proportional to the level of education.
As an integral member of the team, you will
- Autonomously plan, design, and execute biochemical and cell-based experiments to support our I&I pipeline.
- Maintain a hands-on approach while being an open-minded, flexible team player.
- Analyze, interpret and integrate complex datasets across multiple assay types.
- Document data meticulously using ELN and state-of-the-art analyses.
- Stay at the forefront of latest research through literature review and critical evaluation of available data sources.
- Ensure team progress and success through efficient communication with team members across the organization.
Your Qualifications are
- A BSc, MSc, or PhD degree in immunology, molecular and cell biology, biochemistry or a related field, with 8+, 5+ or 2+ years of relevant industry experience, respectively.
- A meticulous and detail-oriented approach to experimental design, with full commitment to scientific rigor and creative solutions.
- A solid understanding of autoimmune and inflammatory mechanisms combined with a passion for pre-clinical drug research as evidenced by previous work experience.
- Proven experience with high-quality, immune-relevant assays for compound profiling and MOA evaluations, including but not limited to activation/proliferation assays, co-culture experiments, cytokine analysis, immune phenotyping, and ex vivo culture and functional profiling of blood.
- Robust experience with multi-color flow cytometry.
- Fluency with MSD, Luminex, or other multiplex assays for bio-analyte quantification.
- Extensive experience in general cell biology, such as isolation, growth and maintenance of cell lines and primary cells, live cell imaging, IF staining, high-content/high-throughput imaging and quantitative image analysis.
- Solid expertise in RNA workflows from isolation/quantification/QC to downstream processing (qRT-PCR, RNAseq).
- Critical understanding of assay development and validation for screening and compound progression purposes.
- A highly organized workstyle with excellent written and oral communication skills.
- Proficiency with data visualization and statistical analysis using contemporary software tools is a must.
- Practical know-how with industry standard equipment like automated plate readers, liquid handlers, and robotic platforms is highly valued.
What we offer
- Participation in the growth of a pioneering company in AI-driven drug discovery.
- Integration into a dynamic, collaborative and forward-thinking environment.
- Engagement with a multidisciplinary team to tackle challenging projects with a meaningful impact on patient lives
In addition, we provide
- Competitive Pay
- Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
- Stock Option Eligibility
- 401(k) Plan
- Open PTO Policy
- Paid Company Holidays
- Free lunch and snacks at our offices
Top Skills
What We Do
Genesis Therapeutics is unifying AI and biotech to accelerate and optimize drug discovery.
We pioneer novel deep learning and molecular simulation techniques to accelerate the development of new medicines.
Genesis raised its $52M Series A from top tech + biotech investors, Andreessen Horowitz, Rock Springs, and T. Rowe Price.
Story: https://techcrunch.com/2020/12/02/genesis-therapeutics-raises-52m-a-round-for-its-ai-focused-drug-discovery-mission/
We deploy our technology to accelerate a pipeline of several internal drug programs.
Furthermore, Genesis has announced two significant, multi-target collaborations with Genentech and with Eli Lilly, the latter of which entailed a $20M upfront payment with a $670M total deal size.
Now we are scaling the team and technology to support many more programs in parallel as well as increasingly difficult protein targets.
We currently have a team (genesistherapeutics.ai/company.html#team) of about 35 people, split 50/50 between our ML / software team and our biochem team of veteran drug hunters in our own wetlab space. Our ML + software engineers are top-notch -- many graduates from MIT, UC Berkeley, Stanford. Previously worked at OpenAI, Google, Facebook, MemSQL, Jane Street, Dropbox, etc.
We're recruiting pure ML research scientists + software engineers (no bio or chem experience expected) to further our core AI platform as well as scale our drug pipeline.
Likewise, we have several openings in chemistry and biology to join our team of biotech + pharma veterans who are deploying the Genesis ML platform to discover novel drug candidates.
Please apply on our website, or feel free to reach out via email directly: [email protected]
