Senior Research Associate/Scientist I – Preclinical Pharmacology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position

We are seeking a motivated and highly skilled Senior Research Associate or Scientist I in our Preclinical Pharmacology group to support the development of novel therapeutics for cancer and inflammatory disorders. The ideal candidate will have expertise in pharmacological profiling of small molecule drugs, xenograft and syngeneic tumor models, mammalian cell and molecular biology, and mechanisms of disease in oncology and inflammation. Specific responsibilities for this role include the design, execution and analysis of in vitro and in vivo experiments, assay development for in vitro and in vivo PK/PD profiling, and presentation of data at project team meetings. The candidate will be expected to work independently and collaboratively across multiple Nurix groups (Discovery Biology, Medicinal Chemistry, DMPK), and to generate high quality, impactful results in an exciting and fast-paced research environment.

Qualifications

• Ph.D. in pharmacology, cancer biology, immunology or related field with 1 year of relevant post-doctoral or industry experience, or M.S. with 5 years of relevant experience, or B.S. with 10 years of relevant experience
• Expertise in oncology, immunology, and in vivo models of cancer and inflammatory disease
• Expertise in small molecule drug development and PK/PD assay technologies
• Expertise in hit-to-lead optimization and establishment of PK/PD relationships
• Expertise in multi-color flow cytometry to profile immune cell populations in primary tissues and immortalized cell lines
• Excellent communication, organization and time-management skills
• Excellent ability to work collaboratively and efficiently with other team members across disciplines
• Excellent ability to address complex scientific problems using hypothesis-driven and methodical approaches

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