The Company
Nurix is a biopharmaceutical company committed to bringing novel, first-in-class therapies to patients. We are a leader in discovering and developing a new class of drugs designed to modulate protein levels in cells through E3 ubiquitin ligase activity within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. Nurix’s scientific team has established an innovative drug discovery platform aimed at identifying novel therapeutics that either modulate E3 ligase function directly or harness it to direct the fate of other disease-relevant target proteins.
Nurix was founded by a team of internationally renowned experts in the fields of E3 ubiquitin ligase regulation and structure. Since its incorporation, Nurix has built a seasoned team of leaders with wide-ranging backgrounds in small molecule drug development and cancer therapy. Through its leadership in Targeted Protein Modulation and its powerful proprietary DELigase platform, Nurix has attracted industry-leading partners, including its current drug discovery collaborations with Gilead Sciences, Sanofi, and Pfizer. Nurix is based in San Francisco’s biotechnology hub, Mission Bay – where academia and industry come together for cutting-edge life-saving research.
The Position
We are seeking a motivated and highly skilled Senior Research Associate or Scientist I in our Preclinical Pharmacology group to support the development of novel therapeutics for cancer and inflammatory disorders. The ideal candidate will have expertise in pharmacological profiling of small molecule drugs, xenograft and syngeneic tumor models, mammalian cell and molecular biology, and mechanisms of disease in oncology and inflammation. Specific responsibilities for this role include the design, execution and analysis of in vitro and in vivo experiments, assay development for in vitro and in vivo PK/PD profiling, and presentation of data at project team meetings. The candidate will be expected to work independently and collaboratively across multiple Nurix groups (Discovery Biology, Medicinal Chemistry, DMPK), and to generate high quality, impactful results in an exciting and fast-paced research environment.
Qualifications
- Ph.D. in pharmacology, cancer biology, immunology or related field with 1 year of relevant post-doctoral or industry experience, or M.S. with 5 years of relevant experience, or B.S. with 10 years of relevant experience
- Expertise in oncology, immunology, and in vivo models of cancer and inflammatory disease
- Expertise in small molecule drug development and PK/PD assay technologies
- Expertise in hit-to-lead optimization and establishment of PK/PD relationships
- Expertise in multi-color flow cytometry to profile immune cell populations in primary tissues and immortalized cell lines
- Excellent communication, organization and time-management skills
- Excellent ability to work collaboratively and efficiently with other team members across disciplines
- Excellent ability to address complex scientific problems using hypothesis-driven and methodical approaches
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Top Skills
What We Do
Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels.
Our drugs control ubiquitin E3 ligases, the key enzymes responsible for protein breakdown in human cells, as a unique therapeutic approach to treat a broad range of diseases.
Our focus is on developing drugs to treat cancer including novel, small molecule immuno-oncology agents
