Senior Research Associate I, Protein Sciences

The Position:

As a Senior Research Associate I on our Protein Sciences Team, you will support the discovery and advancement of new drug targets.  Working closely with a collaborative team, you’ll play a hands-on role in the expression, purification, and structural characterization of proteins that are essential to our therapeutic pipeline.  Reporting to the Head of Protein Sciences, you’ll have the opportunity to expand your expertise in protein science and take on complex challenges that will shape the future of medicine.

Your Impact:

• Contribute to drug discovery efforts by designing and conducting protein expression and purification experiments
• Use a variety of biochemical and biophysical assays, to characterize proteins and protein-small molecule interactions
• Perform protein crystallization trials and support structural analysis
• Partner closely with the drug discovery team to design and execute experiments
• Share your findings in research meetings, with special attention to data quality and reproducibility, supporting data driven discussions that guide our project strategy
• Learn new laboratory techniques, troubleshoot experiments, and uphold rigorous scientific standards to ensure the integrity of every result

Skills and Qualifications:

• Bachelor’s or Master’s degree in Biochemistry or Structural Biology with 5+ years of hands-on experience in recombinant protein production and characterization
• Demonstrated experience in protein production across bacterial, insect and mammalian systems and proficiency in modern chromatography purification techniques
• A strong foundation in protein characterization through biochemical and biophysical methods (e.g. SDS-PAGE, WB, DSF, SPR)
• Familiarity with protein crystallization techniques (both manual and robotic) is a plus
• Exceptional organization, attention to detail, and communication skills, along with the ability to thrive independently and as part of a collaborative team

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, . and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

The expected annual salary range for employees located in the San Francisco Bay Area is $99,000 - $120,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.  

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.