Treeline Biosciences

Senior Research Associate, Biotherapeutics

Posted 8 Days Ago

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Watertown, MA

1-3 Years Experience

Biotech

The Role

The Senior Research Associate in Biotherapeutics will develop and optimize conjugation methods for antibody drug conjugates (ADCs), conduct purification and analysis of ADCs, evaluate properties of lead candidates, and collaborate across teams to advance drug discovery programs.

Summary Generated by Built In

Sr Research Associate, Biotherapeutics

About the role

We are seeking an enthusiastic, and highly motivated scientist to join our team. With a background in conjugation, purification and analytical characterization of antibody drug conjugates (ADCs), and a track record of contributing to multidisciplinary drug discovery teams, this position will play a critical role in driving Treeline’s portfolio forward. You will also play a key role in developing the next generation of ADCs using bioconjugation, biochemistry, analytical chemistry techniques and various state-of-the-art scientific approaches. You will closely collaborate with other biochemists, medicinal chemists, biologists, and pharmacologists to enable forward progress of drug discovery programs.

Responsibilities

Perform, develop and optimize conjugation methods to generate high quality ADCs to support drug discovery campaigns.
Conduct routine purification and analytical characterization of ADCs.
Evaluate physicochemical properties, stability and developability of lead ADC candidates.
Design and conduct well controlled high-quality experiments to answer key scientific questions.
Contribute to evaluation and development of new approaches and technologies within the bioconjugation group.
Closely collaborate with medicinal chemistry, protein science and biology teams.
Maintain an electronic lab notebook in compliance with company policies.
Help establish the bioconjugation group and contribute to building a culture that embraces continuous learning and improvement.

Qualifications

BS or MS in Biochemistry, Chemistry, or related discipline with at least two years of experience in antibody conjugation.
Experience with purification and analytical characterization of ADCs using AKTA, UF/DF, UV-Vis, LC-MS, SEC, SDS-Page is required.
Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on cross-functional, multidisciplinary teams.

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