Senior Director, Biostatistics

The Position

As the Senior Director, Biostatistics, you’ll play a critical role in shaping the development of Maze’s therapeutics by providing expert statistical leadership.  You will work closely with teams across Clinical Science, Regulatory Affairs, Clinical Pharmacology, Development Science, and Translational Science to ensure the integrity and impact of our clinical programs.

In this role, you’ll oversee biostatistical strategy and execution, from study design to regulatory submissions, and be a key contributor to clinical development plans.  You’ll also represent Biostatistics in clinical study teams and interactions with global Health Authorities.  We’re looking for someone who can balance hands-on statistical expertise with high-level strategic collaboration.

The position will report to the Vice President, Clinical Science.

The Impact You’ll Have

• Provide statistical expertise in clinical development plans, study protocols, regulatory documents, publications, and presentations.
• Develop and execute statistical analysis plans, ensuring accuracy, integrity, and alignment with clinical development objectives.
• Collaborate cross-functionally with clinical and regulatory teams to drive program and study success.
• Oversee and manage biostatistics vendors and contract personnel to ensure high-quality outputs.
• Support biomarker research and exploratory data analyses as needed.
• Lead internal efforts to establish SOPs to enable efficient and high-quality execution of clinical studies.

As a Senior Director, we also expect our leaders to demonstrate the following Leadership Competencies: 

• Communication and Influence
  • Builds communication channels across Maze for sharing information.
  • Influences Senior Management decisions through persuasive arguments.
  • Respectfully addresses differing opinions leading to support of decisions.
• Teamwork and Collaboration
  • Champions partnerships and connections across Maze.
  • Proactively addresses issues that could result in breakdown of team relationships.
  • Spotlights team and individual contributions in public forums.
• Execution and Results
  • Addresses gaps and leverages strengths to get best results.
  • Maintains a steadying presence and clarifies priorities during change.
  • Anticipates and removes barriers that put functional/corporate goals at risk.
• Develop Others and Self
  • Remove barriers to staff development and empowers them to make their own decisions.
  • Stays current on industry trends and keeps direct-reports prepared and responsive.

 What We’re Looking For

• PhD in Statistics or Biostatistics with 7+ years of experience working in early- and late-stage clinical development in the pharma/biotech industry.
• Experience with new drug applications (NDAs) or marketing authorization applications (MAAs) is strongly preferred.
• Deep knowledge of clinical study designs, statistical analysis techniques, and regulatory expectations.
• Proficiency in SAS and/or R for statistical analysis.
• Strong problem-solving and project management skills.
• Excellent interpersonal, verbal and written communication skills.
• A collaborative mindset, leading by example, influencing effectively, and fostering teamwork.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease.  Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

The expected annual salary range for employees located in the San Francisco Bay Area is $225,000 to 275,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.