Scientist/Senior Scientist, Immunogenicity

Posted Yesterday
Be an Early Applicant
Brisbane, CA
Mid level
Healthtech • Biotech
The Role
The role involves developing novel assays to investigate immunogenicity, leading lab execution, mentoring junior scientists, and supporting immunogenicity risk assessment in collaboration with cross-functional teams. The scientist will also maintain a human PBMC bank and advance scientific expertise in the field.
Summary Generated by Built In

About the Role

The biology group at Xaira seeks an accomplished immunologist with CD4+ T cell expertise, preferably with direct experience investigating immunogenicity of biologics and/or vaccines. This role will involve investigations into the fundamental biology governing immunogenicity, development of novel assays and supporting immunogenicity risk assessment and mitigation for pipeline programs. They will immediately be responsible for leading the development and execution of assays directly in the lab while actively participating in a variety of interdisciplinary collaborations with machine learning, bioinformatics and proteomics colleagues. This will be an exciting opportunity for a lab based scientist looking to contribute to building a new team and exploring then applying novel biological insights. 

The ideal candidate will have a strong background in immunology, experience with human immune cell isolation and culture, proficiency with immune assay readouts/instrumentation (flow cytometry, cytokine, ELISpot, etc.) and a proven record of managing and mentoring junior scientists. You will have experience with identifying key gaps in knowledge, project conception, strategic planning, timeline management and both leading as well as contributing to cross-functional, interdisciplinary teams. You will both manage direct report(s) and lead by influence. As a founding member of this new team, you will need to provide strategic direction and vision, while effectively communicating horizontally across disciplines and vertically from junior scientist to executive-level management. A demonstrated domain expertise for T cell and/or antigen presenting cell biology as they relate to adaptive immune responses is required. 

Key Responsibilities

  • Develop, troubleshoot, and execute primary human immune cell assays including induction of monocyte derived dendritic cells and activation of T cells.
  • Standardize and scale assays using both semi and fully automated approaches.
  • Liaise with target evaluation and pipeline program teams to provide immunogenicity risk assessment and mitigation support.
  • Data analysis, QC, and management to enable decision making and machine learning approaches.
  • Management of one to several direct reports, training, and mentorship of future team members.
  • Develop forward looking strategies to identify and implement novel assays, measurements, and technologies that increase throughput, quality, and reproducibility of results.
  • Establish, characterize and maintain a human PBMC bank.
  • Present program updates and research strategies to functional and non-functional leaders as well as potential and existing partners.
  • Advance scientific expertise within immunogenicity space by staying up-to-date with literature, attending conferences and participating in industry working groups.

Qualifications

  • PhD with 3+ years experience (industry experience preferred) in Immunology or related field with demonstrated impact within discipline (e.g. strong publication record, conference presentations, etc.).
  • Extensive knowledge and experience of both innate and adaptive systems, experience evaluating immunogenicity of therapeutic proteins and/or vaccines strongly preferred.
  • Proven management and mentorship abilities, including supervising, coaching and developing junior scientists.
  • Direct experience working with primary human immune cells (isolation, cell subset induction, antigen specific activation, etc.) and assessment of routine immune assay readouts (e.g., flow cytometry, bead/ELISA-based cytokine readouts, ELISpot, immunofluorescence, etc.).
  • Demonstrated capabilities in scaling and automating assays strongly preferred.
  • Self-directed and capable of leading multiple complex research projects independently while collaborating with interdisciplinary stakeholders.
  • Ability to promote an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. The base pay range for this position is expected to be $120,000 - $150,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. XairaTherapeutics is not responsible for any fees related to unsolicited resumes.



Top Skills

Immunology
The Company
Brisbane, CA
112 Employees
On-site Workplace
Year Founded: 2023

What We Do

Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease. The company seeks to rethink the drug discovery and development process from end-to-end by bringing together leading talent across three core areas: machine learning research to better understand biology, expansive data generation to power new models, and robust therapeutic product development to treat disease. Xaira is headquartered in the San Francisco Bay Area

Similar Jobs

Brisbane, CA, USA
112 Employees
Brisbane, CA, USA
112 Employees

Capital One Logo Capital One

Principal Data Scientist - The AI Training Team

Fintech • Machine Learning • Payments • Software • Financial Services
Hybrid
San Jose, CA, USA
55000 Employees
165K-200K Annually

Block Logo Block

Staff Data Engineer, Public Web

Blockchain • eCommerce • Fintech • Payments • Software • Financial Services • Cryptocurrency
Remote
Hybrid
7 Locations
12000 Employees
153K-270K Annually

Similar Companies Hiring

Sage Thumbnail
Software • Healthtech • Hardware • Analytics
New York, NY
44 Employees
Zealthy Thumbnail
Telehealth • Social Impact • Pharmaceutical • Healthtech
New York City, NY
13 Employees
Cencora Thumbnail
Pharmaceutical • Logistics • Healthtech
Conshohocken, PA
46000 Employees

Sign up now Access later

Create Free Account

Please log in or sign up to report this job.

Create Free Account