Scientist, Therapeutic Discovery

Janux is seeking a highly motivated Scientist with demonstrated skills in standard assay execution related to multi-specific antibody discovery and screening methods. The candidate will participate in hands-on pre-clinical drug discovery and development programs with a focus on quantitatively characterizing antibody binding, biophysical and functional characteristics. The candidate will characterize and develop large molecules as a key member of the drug discovery team. The successful candidate will have extensive hands-on experience with standard immunological and cancer biology techniques (ELISA, Octet BLI or biacore SPR, cell-based reporter and functional assays, flow cytometry and others).

This position is hands-on and requires the effective communication and documentation of results that enable the advancement of novel research molecules toward development candidates. Ideal applicants will be collaborative and team-oriented, possess excellent communication and organizational skills, and carry a strong commitment to excellence.

Duties and Responsibilities:

• Perform quantitative ELISA-based characterization of peptides and antibody molecules (96 and 384 well)
• Conduct basic protein analysis: SDS-PAGE, Western blot and protein quantification
• Perform and analyze protein-protein interaction and kinetic assays (BLI,Octet)
• Perform mammalian cell culture and cell banking
• Conduct and help develop new cell-based in vitro assays: cell-mediated cytotoxicity, functional reporter
• Conduct basic flow cytometric staining and analysis
• Complete quantitative analyses and basic interpretations of experimental data
• Produce detailed documentation of experiments within a lab notebook and electronically
• Conduct and report laboratory experiments on a daily basis
• Conduct multiple research activities in parallel
• Comfortably work with Excel and Graphpad Prism software
• Clearly communicate data to supervisor and in team meetings
• Other duties as deemed necessary

Required Skills/Qualifications:

• Bachelor’s degree in biology, biochemistry, bioengineering, chemical biology, or related scientific discipline with 6+ years of experience in biotech/pharmaceutical industry, or Master’s degree with 4+ years of experience, or PhD with 2+ years of post-doc experience.
• Experience with flow cytometry cell staining, acquisition and analysis, ELISA, SDS-PAGE, western blot, and other standard cell based & non-cell based quantitative biochemical assays.
• Experience bio-layer interferometry (BLI) Octet assay setup and analysis
• Skilled in basic tissue culture techniques (cell expansion and banking) and aseptic handling of material
• Experience with in vitro cell-based assays (Drug-induced cell-mediated cytotoxicity using real-time xCELLigence RTCA and Incucyte highly preferred, or luminescence-based)
• Experience with flow cytometry and data analysis (FlowJo or similar software)
• Experience completing quantitative plate based biochemical assays using various plate readers
• Experience quantifying results in Excel and Graphpad Prism
• Occasional weekend and/or holiday availability may be requested

Job Type: Full-time

Benefits:

· 401K

· Medical insurance

· Dental insurance

· Vision insurance

· Supplemental disability insurance plans

· Flexible schedule

· Life insurance

· Flexible vacation

· Sick time

· Incentive stock option plan

· Relocation assistance

Schedule:

· Monday to Friday

Work authorization:

· United States (Required)

Additional Compensation:

· Annual targeted bonus X%

Work Location:

· On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.