Scientist, Neuroimmunology

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

In vivo pharmacologist with extensive experience to develop and validate new cell-based assays and in vivo disease models to support identification, optimization, and characterization of novel drug candidates. Conducts essential experiments to help determine and characterize mechanism of action (MoA). Execute experiments and support the validation of novel drug targets via multiple mechanisms in vitro and in vivo. Analyze and present data to team in an organized and timely manner. Work within and support biology needs of drug discovery teams.

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Your Contributions (include, but are not limited to):

• Performs assigned experiments that support scientific activities and project goals, in vitro and in vivo

• Collaborates with team members to develop and validate in vitro assays and in vivo animal disease models

• Conduct research innovatively with independent ideas and approaches to answer team’s biology questions and solve issues

• Experienced therapeutic Ab discovery

• Responsible for developing in vivo animal disease models including autoimmune diseases and neurodegenerative disease models

• High skills of animal handling, drug dosing and surgery of various tissues from disease model and

• High skills of cellular assay including cell line, primary cells from human and rodents, ex vivo assay from animal models

• Understand and perform flow cytometry assay and immune cell function assay including isolating primary immune cells, cytokine assays, cell differentiation and functional assays, ligand-mediated signal transduction etc.

• Maintains SOP’s and writes data summaries for experiments conducted

• Reviews, comprehends and complies with all SOP’s, and safety and quality assurance standards at all times

• Provides training and/or supervision to junior staff, as needed

• Other duties as assigned

Requirements:

• BS/BA degree in biology and 2+ years of relevant experience OR

• MS/MA degree in biology and some relevant industry experience preferred OR

• PhD or equivalent and Some relevant experience

• Knowledge of the principles of biology and chemistry, including pharmacology & cell biology

• Experience with tissue culture techniques, including aseptic technique, primary and immortalized cell line development & management

• Extensive experience of in vivo animal disease model development of various autoimmune diseases and neurodegenerative models

• Knowledge and experience of in vivo pharmacokinetics and pharmacodynamics studies

• Extensive experience of handling animals and testing drug candidate as well as ex vivo assays of primary cells from the various disease models

• Knowledge and experience of immunology research and therapeutic Ab discovery

• Critical thinking of disease models and investigate drug candidate efficacy and capable of investigating the mechanism of action of drug candidiates in vitro and in vivo

• Basic knowledge of NGS technologies, their implementation, and data analysis & relevant statistical tests

• Knowledge and extensive technical skills of tissue processing techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH and RNAseq

• Knowledge and experience in cellular signaling, phenotyping, differentiation and functionality analysis

• MAbs/bi specifics - understanding of antibody protein structure & function and assays applied for Ab discovery

• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes

• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals

• Good knowledge of scientific principles, methods and techniques

• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team

• Strong computer skills

• Good communications, problem-solving, analytical thinking skills

• Detail oriented

• Ability to meet deadlines

• Good project management skills

#LI-OB1

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $88,000.00-$127,550.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.