Scientist 3, Peptide Therapeutics

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We are seeking a passionate, collaborative, and innovative Peptide Medicinal Chemist to join our dynamic drug discovery team focused on Peptide Therapeutics. This role offers an exciting opportunity to work at the cutting edge of medicinal chemistry, contributing to the design, synthesis, and optimization of novel peptide-based therapeutics. As an integral part of an interdisciplinary and agile research environment, you will work closely with cross-functional teams to drive our mission of transforming scientific discoveries into life-changing therapies.

This role is a unique opportunity for a skilled medicinal chemist to play a pivotal role in a fast-paced, innovative environment, where scientific collaboration and agility drive breakthrough discoveries in peptide therapeutics. Join us in pushing the boundaries of what’s possible in peptide drug discovery!

The Opportunity:

• Design and Innovation: Conceptualize and synthesize novel peptides and peptidomimetics to advance our drug discovery pipeline, utilizing structure-based design and computational chemistry approaches to enhance properties, target engagement, potency, and selectivity.

• Data-Driven Optimization: Leverage data from structural biology and DMPK (drug metabolism and pharmacokinetics) studies to iteratively refine peptide leads, ensuring optimal pharmacokinetic and pharmacodynamic profiles for clinical development.

• Cross-Functional Collaboration: Partner with biology, pharmacology, structural biology, and ADME teams to accelerate lead optimization and candidate selection. This role will actively contribute to strategic decision-making across disciplines, fostering a culture of agility, innovation, and scientific excellence.

• Technical Expertise and Method Development: Develop and implement novel synthetic methodologies, including peptide cyclization and ligation techniques, to expand the chemical space and diversify our peptide library.

• Record Keeping and Knowledge Sharing: Maintain rigorous experimental documentation, contributing to internal knowledge-sharing and publishing findings in high-impact scientific journals and presentations.

Who you are:

• Educational Background: Ph.D. in Medicinal Chemistry, Organic Chemistry, Chemical Biology, or a closely related field with a concentration in peptide chemistry

• Industry or academia experience: has >3 years relevant experience in medicinal chemistry

• Advanced Synthetic Chemistry Skills: Proven expertise in peptide, peptidomimetic, and amino acid building block synthesis, with a strong focus on cyclization methodologies and chemical ligation techniques

• Analytical Proficiency: Demonstrated experience with peptide characterization methods, including HPLC, MS, and NMR, with the ability to interpret complex datasets and apply insights to design optimization

• Structure-Based Drug Design: Proficiency with molecular modeling and structure-based design tools, with an understanding of how to apply these methods to develop peptides with enhanced binding affinity and selectivity

• Track Record of Scientific Rigor: A history of scientific excellence demonstrated through peer-reviewed publications, patents, and conference presentations

• Collaborative Mindset: Strong interpersonal skills and a commitment to teamwork, with an ability to thrive in an interdisciplinary and collaborative research setting

• Communication and Agility: Excellent communication skills, with the ability to convey complex scientific concepts clearly to diverse audiences. Demonstrates agility in adapting to shifting project priorities and timelines

Preferred:

• Pharma industry experience

Relocation benefits are available for this job posting

The expected salary range for this position based on the primary location of California is $100,200 and $186,000 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.