Research Associate/Senior Research Associate, Strategic Molecular Systems Engineer

Colossal is looking for a talented biologist with a strong interest in applying synthetic biology to create innovative genetic constructs for the modification of mammalian traits. In this high-impact role, you will work closely with a cross-functional team to drive novel applications in the modification of phenotypes across a variety of species. You will have the opportunity to significantly influence the direction of the project and make an impact across Colossal.
This position is based on-site in Dallas, TX. Relocation assistance is available. 

Duties and Responsibilities: 

• Perform molecular cloning and troubleshooting of plasmids and gene constructs.
• Genotype clones of interest and resolve any issues in the process.
• Work to improve throughput in clonal generation by integrating automation into molecular and cellular workflows.
• Collaborate with stem cell biologists to optimize gene editing and novel gene integration delivery methods in mammalian models.
• Analyze and interpret data, making informed decisions to steer the project forward.
• Contribute to patent generation, helping to protect innovative work and discoveries.
• Attend lab meetings, prepare reports, and present findings to ensure team alignment and progress on milestones.
• Demonstrate excellent organizational skills and maintain accurate, detailed lab records.

Required Skills and Abilities:

• Strong hands-on research experience with molecular cloning, plasmid troubleshooting, and gene construct development.
• Experience with gene-editing tooling (CRISPR / Cas9 HDR).
• Proficient in molecular biology techniques, including DNA/RNA extraction, protein isolation, and qPCR.
• Experience with genotyping design and troubleshooting assays in cellular and mouse models.
• Excellent organizational skills, ability to handle multiple projects concurrently, and meet deadlines.
• Strong written and oral communication skills, along with creative problem-solving abilities.
• Adaptability in a fast-paced, dynamic work environment.

Preferred Skills and Abilities:

• Experience tagging proteins with fluorophores and expressing fluorophores from ectopic & native enhancers.
• Experience with high-throughput automation platforms.
• Familiarity with plate reader instruments and Shimadzu UV-Vis Software.
• Experience working with bacterial expression systems and their application to mammalian models.

Education and Experience:

• BA/BS/MA/MS in biological sciences, bioengineering, molecular biology, genetics, or any science related field.