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Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.
RESEARCH ASSOCIATE / SR. RESEARCH ASSOCIATE, NONCLINICAL DEVELOPMENT
Responsibilities:
- Collaborate and communicate effectively with members of the Nonclinical Development team and other cross-functional scientists.
- Prepare and execute in vivo studies using xenograft mouse models to evaluate the pre-clinical efficacy of cell-based cancer therapeutics. Includes animal preparation, tumor implantation (disseminated, subcutaneous, orthotopic), dosing of therapeutics via various routes of administration, monitoring tumor growth by IVIS imaging or caliper measurements, and survival and terminal tissue and blood collections for ex vivo analysis.
- Maintain tissue cell cultures and process tissue samples for flow cytometry analysis and other assays to elucidate mechanism of action.
- Collect, enter, and analyze study data in ELN systems and generate study reports. Summarize and present data in group meetings and other forums as needed.
- Maintain vivarium experimental equipment and ensure the availability of appropriate materials and reagents for study activities.
Qualifications:
- BS or MS in biological sciences with a minimum of 2 years of experience in a research laboratory, preferably in an industry setting.
- Prior experience handling research rodents, particularly immunocompromised mice, for pre-clinical assessments of cancer therapeutics using xenograft and/or syngeneic tumor models required.
- Proficiency in animal dosing techniques (i.v., s.c., i.p.) required.
- Proficiency with mammalian cell culture techniques such as thawing, cell line passaging, cell counting and bank cryopreservation required.
- Prior experience preparing and analyzing tissue samples for flow cytometry and operation of live animal imaging equipment for monitoring of bioluminescence/fluorescence is a plus.
- Must be able to work in a dynamic team environment and communicate effectively in both spoken and written forms.
- Effective trouble shooting and problem-solving skills.
Should not have allergies to laboratory rodents which impedes working in a vivarium.
Pay Range
$85,000—$118,000 USD
Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.
At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting autoimmune diseases and cancer.
We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.
To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.
We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave.
Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms.
Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Top Skills
What We Do
At Adicet (Nasdaq: ACET), we are defined by our mission to deliver best-in-class gamma-delta T cell therapies for patients fighting cancer. Every one of our team members, whether in the lab, manufacturing, or general business role, comes to work every day with the patient in mind.
As pioneers in the cell therapy space, we are honored and humbled by the opportunity to put our talents to bear in developing transformative therapies to defeat cancer. We believe that the best way to do this is through discovering and developing allogeneic gamma-delta T cell therapies, a novel type of cell therapy.
Adicet has chosen the gamma-delta T cell because it has multiple ways to target and kill cancer cells, which may provide a better chance of achieving complete and durable responses to therapy. Additionally, instead of using cells from the already sick cancer patient, Adicet uses cells from unrelated donors (allogeneic) because they are reliable and readily available allowing us to rapidly and cost-effectively scale production of these medicines and make them available when needed (“off-the-shelf”).
Specifically, as a clinical stage biotechnology company we are advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CAR) and T cell receptor-like antibodies (TCRL) to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients.
