Our lab in San Diego is looking for a motivated and multiskilled Research Associate with experience in biophysics and protein sciences to help drive rapid progress in our drug programs across a variety of different targets. The successful candidate will design and execute various biophysical assays to investigate drug-target interaction kinetics and binding properties. This role will play a vital role in project progress across the portfolio from initial hit ID to hit to lead and lead optimization stages.
What You Will Do:
- Design and execute routine biophysical assays from beginning to end using methods such as SPR, DSF, and other biophysical techniques to characterize small molecule-protein interactions.
- Routinely and independently analyze & QC experimental data.
- Program, validate, and operate liquid-handling automation (Biomek Liquid handler, Multidrop Combi, Integra Viaflo & Voyager) for 384-well plate-based assays and use instrumentation such as plate readers for reproducible, publication-quality data generation.
- Communicate results efficiently & precisely in written format by maintaining electronic lab notebook.
- Presents work to supervisor, lab and/or project meeting.
What You Will Bring:
- B.S./M.S. in Biochemistry, Biophysics, or a related field with minimum 1 year of academic or industry lab experience.
- Experience with biophysical methods such as SPR, ITC, MST, or other biophysical technique is preferred.
- Familiarity with lab automation/instrumentation is preferred.
- An eagerness to learn new techniques and keeping up to date with the latest ligand-binding technology.
- Ability to work efficiently and deliver results within timelines while maintaining a high attention to detail ensuring reliable and reproducible data generation.
- High attention to detail & excellent problem-solving skills.
Top Skills
What We Do
Genesis Therapeutics is unifying AI and biotech to accelerate and optimize drug discovery.
We pioneer novel deep learning and molecular simulation techniques to accelerate the development of new medicines.
Genesis raised its $52M Series A from top tech + biotech investors, Andreessen Horowitz, Rock Springs, and T. Rowe Price.
Story: https://techcrunch.com/2020/12/02/genesis-therapeutics-raises-52m-a-round-for-its-ai-focused-drug-discovery-mission/
We deploy our technology to accelerate a pipeline of several internal drug programs.
Furthermore, Genesis has announced two significant, multi-target collaborations with Genentech and with Eli Lilly, the latter of which entailed a $20M upfront payment with a $670M total deal size.
Now we are scaling the team and technology to support many more programs in parallel as well as increasingly difficult protein targets.
We currently have a team (genesistherapeutics.ai/company.html#team) of about 35 people, split 50/50 between our ML / software team and our biochem team of veteran drug hunters in our own wetlab space. Our ML + software engineers are top-notch -- many graduates from MIT, UC Berkeley, Stanford. Previously worked at OpenAI, Google, Facebook, MemSQL, Jane Street, Dropbox, etc.
We're recruiting pure ML research scientists + software engineers (no bio or chem experience expected) to further our core AI platform as well as scale our drug pipeline.
Likewise, we have several openings in chemistry and biology to join our team of biotech + pharma veterans who are deploying the Genesis ML platform to discover novel drug candidates.
Please apply on our website, or feel free to reach out via email directly: [email protected]
