Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (previously BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
- We are One Team. We only succeed when we work together.
Job Description
Bicycle Therapeutics is hiring for a newly created Procurement Manager role to help support the CMC function of our company. As a vital member of the team, you will help lead the CMC supplier management process, which includes creating & coordinating routine business reviews, leading escalation meetings, and resolving business action items. In addition to leading the CMC supplier management process, this role will help identify and implement continuous improvement elements to our RFI/RFP process.
Key responsibilities:
- Lead the CMC supplier management process, including the coordinating routine business reviews, escalation meetings, and ultimate action item follow-up
- Build and report out a strategic view of the supplier business relationship.
- Evaluate the supply quality, and compliance of our entire CMC supply base
- Create and oversee the cadence of a set schedule of both in-person and virtual meetings is across CMC programs
- Responsible for generating & coordinating business review pre-reads, meeting notes, and action item logs for each business review
- Assist in Request for Information (RFI) and Request for Proposal (RFP) documentation process
- Assist in the compilation and distribution of Key Performance Indicators (KPI’s) from Bicycle® suppliers
- Review and draft CMC vendor policy documentation
- Support vendor onboarding activities
- Support the Purchasing Order and Contract Approval Form (CAF) sourcing process
- Act as a key liaison between Procurement and other cross-functional teams/stakeholders
Qualifications
Essential:
- Knowledge of Chemistry, Manufacturing and Controls (CMC)
- Experience in Supplier Relationship Management (SRM)
- Ability to build consensus among internal stakeholders
- History of working with and/or establishing an end-to-end sourcing process
- Understanding of Procurement policies and guidelines
Desirable:
- Highly collaborative, strong relationship building skills with a high level of integrity and emotional intelligence.
- First class communication and influencing skills with the ability to manage multiple stakeholders.
- Resilient and able to work effectively in a demanding and fast-paced environment.
- Understanding of supplier GMP requirements
- Worked within an international and/or hybrid team dynamic
Other:
- Hybrid base role. Expectations of at least one day per week in Cambridge USA office
- Less than 10% domestic travel considerations
- CPSM or APICS certification preferred
- Six Sigma certification preferred
- Educated in Supply Chain Management preferred
Additional Information
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with a 4% Company match and immediate vesting
- Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
- Employee assistance program
- Employee recognition schemes
- 10 Company holidays
- Competitive Family Leave Policy
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
What We Do
We are Bicycle Therapeutics, a clinical-stage biopharmaceutical company. We didn’t wait for the next advance against cancer. We created it.
Based on groundbreaking work conceived in the laboratory of Sir Greg Winter with the help of Professor Christian Heinis, we are pioneering the development of bicyclic peptides, or Bicycles® – a novel class of versatile, chemically synthesized medicines. Bicycles are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint is designed to confer high affinity and selectivity, and the relatively large surface area presented by the molecule allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycles represent a unique therapeutic class, combining the pharmacological properties normally associated with a biologic with the manufacturing and pharmacokinetic advantages of a small molecule, yet with no signs of immunogenicity observed to date.
Bicycles can be used as Bicycle conjugates to deliver toxin payloads and to precisely target local immune activation within tumors and as Bicycle T-cell modulators, which activate cytotoxic T-cells while circumventing the limitations of antibody and biologic therapies and better enabling combination therapy. Our lead product candidate, BT1718, is a Bicycle toxin conjugate currently being investigated in a Phase I/IIa open label dose escalation and expansion clinical trial sponsored by Cancer Research UK. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MMP), also known as MMP-14, which is highly expressed in many solid tumors.
Our strategic collaborations are based on the ability of Bicycles to address a wide variety of targets. Through collaborations with AstraZeneca, Oxurion, Innovate UK and the Dementia Discovery Fund, we work with companies that have deep therapeutic expertise outside of oncology to enable us to more efficiently develop novel medicines for patients.
