Director, Portfolio & Program Strategy

The Role
Moderna is advancing its mRNA platform to unlock new therapeutic applications and expand its R&D portfolio across multiple disease areas. To maximize impact, the Portfolio & Program Strategy team plays a critical role in ensuring that portfolio investments are strategic, data-driven, and aligned with corporate priorities. This team operates across research, development and commercial functions to provide structured insights and enable executive decision-making.

The Director, Portfolio & Program Strategy, will be responsible for leading portfolio strategy projects and providing strategic investment recommendations. This individual will tackle Moderna’s most complex investment and prioritization questions, integrating scientific, financial, and strategic insights to drive high-impact decisions. As a strategic thought partner, they will ensure that portfolio and program strategies align with Moderna’s broader corporate objectives.

Here’s What You’ll Do

• Establish structured decision frameworks and processes to enable resource allocation, sequencing, and investment pacing based on real-time data and evolving priorities. 

• Partner with cross-functional teams (research, clinical development, commercial, manufacturing) to drive alignment on portfolio priorities, trade-offs, and strategic pivots.

• Assess the scientific, operational, and commercial impact of portfolio choices, ensuring enterprise-wide coordination while working closely with senior stakeholders. 

• Develop and refine portfolio models that integrate R&D attrition, clinical probability of success, commercial forecasts, and investment pacing to inform decision-making. 

• Deliver clear, data-driven insights and strategic recommendations to executive leadership, translating complex trade-offs into actionable, high-impact moves. 

• Continuously evaluate market, competitive, and internal pipeline dynamics to refine Moderna’s investment strategy.

Here’s What You’ll Need (Minimum Qualifications)

• 8+ years of experience in strategy, corporate development, or portfolio management within a clinical- or commercial-stage pharmaceutical/biotech company, or equivalent experience in management consulting (life-sciences focused), investment banking (healthcare sector) or venture capital (biotech/life sciences).

• Ability to perform and synthesize in-depth analyses of indications, products, and therapeutic areas, integrating findings into actionable recommendations.

• Advanced degree preferred (PhD, MD, PharmD, or MBA), with a strong understanding of drug development, R&D strategy, and value creation in biopharma.

• Demonstrated ability to work cross-functionally across research, clinical development, commercial, and manufacturing teams.

• Experience in portfolio modeling, scenario planning, or strategic investment frameworks.

Here’s What You’ll Bring to the Table (Preferred Qualifications)

• Advanced verbal and written communication skills to deliver a compelling narrative/message to senior stakeholders in the organization

• Experience in biopharma investment analysis, forecasting, or corporate strategy at a global level.

• Ability to translate scientific and financial trade-offs into executive-level decision-making insights.

• Familiarity with clinical trial design and regulatory pathways to understand pipeline development and market entry challenges.

• A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
• Family care benefits, including subsidized back-up care options and on-demand tutoring
• Free premium access to fitness, nutrition, and mindfulness classes 
• Exclusive preferred pricing on Peloton fitness equipment
• Adoption and family-planning benefits
• Dedicated care coordination support for our LGBTQ+ community
• Generous paid time off, including:
  •    Vacation, sick time and holidays
  •    Volunteer time to participate within your community
  •    Discretionary year-end shutdown
  •    Paid sabbatical after 5 years; every 3 years thereafter
• Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
• 401k match and Financial Planning tools
• Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Complimentary concierge service including home services research, travel booking, and entertainment requests
• Free parking or subsidized commuter passes
• Location-specific perks and extras!

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. 

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.
We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute and make a meaningful impact.
If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at [email protected].  (EEO/AAP Employer) 

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