Company Overview
Beam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam Therapeutics is seeking a highly talented Director with deep expertise in mRNA process development, optimization and scale-up. The suitable candidate will have a good understanding of mRNA science with experience in mRNA production, purification, and characterization. The ideal candidate is an inspirational leader with broad experience driving development activities for early and late-stage programs and a firm grasp on Quality by Design principles. This role will be responsible for leading a group of development scientists working on evaluation and process optimization of mRNA production.
Responsibilities:
- Accountable for mRNA manufacturing process development, scale-up, and tech transfer
- Lead team of development scientists in evaluation and optimization of mRNA manufacturing processes
- Establish team goals and standards that are consistent with company priorities and objectives
- Define long term mRNA process development objectives and strategies
- Serve as mentor to team – providing career coaching and technical guidance
- Work cross-functionally to identify areas of risk, drive continuous improvement, and champion operational excellence with internal and external partners
- Analyze, interpret, and present data to internal and external audiences using various formats
Qualifications:
- PhD degree and 10 to 12 years’ experience or MS degree with 15 years process development experience in a Pharmaceutical or CDMO organization
- Previous experience with mRNA manufacturing process is a must
- Good understanding of cGMP manufacturing guidelines
- Prior experience with tech transfer of mRNA, Oligos, Biologics process highly desirable.
- Knowledge of key analytical testing of oligos and mRNA is desirable
- Proven Leadership
- Good communication skills.
- Strong work ethic
Top Skills
What We Do
Beam Therapeutics, launched in 2018, is pioneering the use of CRISPR base editing to develop a broad portfolio of advanced genetic medicines. Our groundbreaking base editing technology allows us to make permanent, specific edits to single bases in DNA and RNA, without cutting the strands. Base editor therapeutics represent a new class of “precision genetic medicines,” combining precision targeting of the genome with precision control of editing outcomes.
Our dream is to provide life-long cures for patients suffering from serious diseases.
The Beam Team Is:
• A community of fearless innovators
• Rigorous and honest in our research
• Listening with open minds
• Committed to each other
