Clinical Genomics Scientist I - US Remote Capable

You + Helix

Helix is a place where innovators and doers gather in order to drive significant progress in population genomics. We have come together to work at the intersection of clinical care, research, and genomics.  

If you’re excited by the idea of making a meaningful impact and joining a team where we pride ourselves on driving innovation through fostering an environment with an emphasis on empowering one another to grow, Helix might be the place for you!

Helix + The World

Helix is the leading population genomics company. Helix enables health systems, public health organizations and life science companies to accelerate the integration of genomic data into patient care and public health decision making.

Helix + Transparency

At Helix, we value transparency. You will find the expected compensation, interview process, what to anticipate during onboarding, and your first 90 days listed in the job description for all Helix roles.

What is special about this role?

The Department of Clinical Genomics is new to Helix, it is like a start-up within a start-up with ample opportunity for growth. You will be working on a variety of tasks,  have the opportunity to bring your ideas to the table, and contribute to the overall success of our team and the company. In the Clinical Genomics team, you will enjoy a strong sense of community and will have the support you need to ensure you can deliver on the expectations of your role. 

As a Clinical Genomics Scientist I, you will:

• Be responsible for variant and gene assessments including researching the significance of variants in published literature and clinical data, evaluating evidence for gene-disease associations, and performing data review.
• Perform technical review of sequencing data derived from NGS, including genome, exome, panel, and single-site variant data, as well as other molecular assay data.
• Troubleshoots complex cases.
• Compile interpretive variant summaries and contribute to clinical report writing.
• Contribute to in-house interpretation workflow development of process documentation.
• Communicate clearly with internal and external stakeholders, such as genetic counselors, physicians, lab staff, and product developers.
• Maintain laboratory variant knowledgebase and assists with curation and harmonization of variant classification changes over time.
• Perform variant classification quality controls and maintain quality management programs according to written policies and procedures.
• Actively participate in continuing education series including journal clubs, complex variant discussions/presentations, and conferences, as needed.
• Train junior team members, as needed.
• Contribute to research projects as necessary.

About you:

• MS or PhD degree with expertise in molecular genetics, human genetics, molecular pathology, or related fields.
• At least 2+ years of experience in clinical variant classification preferably in one or more of the following disease areas: Cardio, Epilepsy, Parkinson’s and Polycystic Kidney Disease.
• Working knowledge of ACMG/AMP Variant Classification Guidelines and their modifications by ClinGen expert panels.
• Familiarity with human mutation databases, genome browsers, HGVS nomenclature, and in-silico variant pathogenicity predictors.
• Able to perform technical writing, as well as strong communication and computer skills.
• Excellent analytical skills and attention to detail.
• Able to critically read and distill data from the scientific literature. 
• Must be able to adjust to shifting priorities according to workload or business needs.
• Able to critically assess and augment processes and workflows.

Pluses:

• Experience with gene-disease validity curations based on ClinGen protocols.
• Familiarity with Integrative Genomics Viewer. 
• Experience in cardio and/or cancer disease area

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. For more information or to make an accommodation request reach out to [email protected]. 

Expected Interview Process:

1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite  4) Offer 

Expected Pay For This Role:

There are 3 distinct parts to your Helix offer: 1) Base Salary  2) Annual Bonus 3) Equity 

Expected Helix Base: $78,000 - $120,000 

Expected Helix Discretionary Annual Bonus: 10% of your annual salary

Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.

The salary range above is our reasonable estimate of the base compensation for this role across US locations. Actual starting pay will be based on non-discriminatory job-related factors, including exact work location, experience, relevant training and education, and skill level. Your recruiter can share more about your specific work location salary range during the hiring process. 

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

• Comprehensive Health Insurance with Date of Hire eligibility 
• Above average employer paid premium coverage 
• 12 weeks Helix Paid Parental Leave option 
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
• Comprehensive Well-Being Benefits 
• 18 well-being programs covering financial, legal and wellness solutions
• Flexible PTO
• Remote options for many roles and a home office stipend 

What To Expect During Your Onboarding Week:

We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms. 

What To Expect During Your First 90 days:

First 30 days:  you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.  

Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.

Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission. 

Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.

#LI-Remote