Bioanalytical Principal Scientist

Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco. 

Visit https://lyciatx.com/ for more information.

The Role:

Lycia Therapeutics is seeking an experienced, organized, and collaborative Bioanalytical Scientist to support a growing Development pipeline. The successful applicant will work with internal and external stakeholders to develop and execute the bioanalytical strategy enabling the advancement of Lycia products from preclinical into and through the clinic. A strong knowledge of bioanalytical assay development, validation, and implementation is essential, as is demonstrated excellence in working with and supporting cross functional teams.

Key Responsibilities:

• Build and execute bioanalytical strategies for supporting early-to-late stage development biotherapeutic programs
• Represent bioanalysis on relevant project teams
• Support development, testing, and transfer to CROs of internal bioanalytical assays (PK, PD, ADA) and methods
• Identify, select and manage contract research organizations in the transfer, development, validation, and sample analysis for non-GLP and GLP bioanalytical assays and soluble biomarkers to support nonclinical and clinical development programs
• Oversee the technical and scientific activities of work conducted at CROs
• Establish and ensure compliance with project and study timelines
• Effectively partner with Research bioanalytical team on ensuring end-to-end execution of bioanalytical and soluble biomarker assays
• Effectively partner with Clinical, Clinical Pharmacology, and Clinical Operations to ensure that bioanalytical strategies, timelines, and deliverables are aligned with Development requirements

Requirements:

• PhD in relevant discipline (eg immunology, biomedical engineering, protein chemistry, ect) with 5+ years of relevant experience, MS with 7-10+ years of relevant experience, BS/BA with 10+ years of relevant experience. Previous biopharma industry experience in bioanalysis is essential
• Experienced in successfully managing external partners in the execution of regulated bioanalysis
• Strong and proactive communication skills
• Adept at influencing key stakeholders
• Highly collaborative across multiple disciplines and situations
• Expert in the conduct of regulated assays, including knowledge of relevant Regulatory guidances and key scientific publications (white papers, ect)
• Willing to conduct laboratory work to ensure that assays and reagents are fit for purpose to ensure smooth and efficient transfer to CROs and to provide troubleshooing for assays during development
• Keenly timeline and deliverable focused, including building and maintaining timelines and budgets associated with relevant activities

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status