2025 Summer Internship, Neuroscience

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.

In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: vepdegestrant for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer; ARV-102 for the treatment of patients with neurodegenerative disorders, and ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas.

In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024.

#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com. 

Position Summary

We are looking for a motivated individual to work as a summer intern (3-4 months) within Neuroscience. This position will be dedicated to conducting experiments and executing assays involving cultured cells, animal tissue, or isolated proteins to develop protein degrader small molecules. This position reports to an Associate Director or another member of the Neuroscience group.

This will be a full-time, on-site position located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• >75% lab work: conduct experiments and analytical assays involving cell culture, protein detection, or protein:ligand interactions.
• Execution of assays to query targeted protein degradation: western blots, ELISA, reporter assays, etc.
• Use of lab automation for compound handling.
• Learn protein degrader pharmacology and data analysis.
• Apply excellent organizational skills to maintain lab stocks and lab cleanliness.
• Maintain clear experimental records and communicate well with supervisor and other team members.
• Deliver critical data by following provided protocols and guidance.

Qualifications

• Motivated and productive individual with excellent communication skills who works effectively in a team setting.
• Prior lab experience is required.
  • Experience with aseptic mammalian cell/tissue culture is required.
  • Experience with antibody-based detection of proteins is strongly preferred.
  • Some experience with 96- or 384-well plate-based assays is preferred (e.g., ELISA, colorometric assays, cell growth assays).
• Basic understanding of cell biology, molecular biology, and biochemistry through coursework.
• Organized, goal-oriented, and timeline-conscious.
• Other preferred skills and knowledge.
  • Experimental documentation/lab notebook.
  • Data presentation.
  • Experience with Microsoft Office suite (Word, Excel, PowerPoint).
• A strong work ethic and willingness for continued learning.
• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without the need for a current or future VISA sponsorship.  
• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

• Current 3rd or 4th year undergraduate or a graduate student with a background in the biological sciences and an interest in Neuroscience.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group, and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com