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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.
Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.
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Job Description
Gilead Sciences Research has a new opportunity for a motivated Research Associate to join our Protein Biochemistry team. Our goal is to develop, build, produce, purify, and validate target proteins to support small and large-molecule drug discovery projects covering a variety of therapeutic areas including inflammation, oncology, and virology.
We are looking for a candidate who will play a critical and independent role in our team. This individual will be responsible for planning and conducting protein production experiments to facilitate R&D activities and project objectives. With guidance, the candidate will assist other functions and teams by performing routine experiments such as preparing recombinant proteins for biochemical assays, structure determination, and in vivo studies. We are seeking a confident, proactive, and dedicated individual with proven experience in protein sciences, who is eager to learn new skills and fully understands the impact of their contributions to our success.
Key Responsibilities:
- Perform protein expression, purification and QC characterizations of recombinant proteins to support drug development in multiple therapeutic areas
- Proactively troubleshoot purification challenges and develop purification process and strategies
- Excellent oral and written communication. Good understanding of scientific data and update project teams of protein status.
- Actively participate in group meetings, present the results, interpret data, and draw conclusions regarding presented material.
- Maintain awareness of cutting-edge technical developments and scientific knowledge and apply these where possible to improve process efficiency.
Qualifications:
- Strong background in protein sciences and protein biochemistry
- BS degree with 2+ years in related scientific discipline or MS degree in related scientific discipline with no industry experience. Preferred experience: BS with 4+years and MS with 2+years direct experience in expression and purification of a variety of recombinant proteins
- Extensive hands-on experience in purification techniques including affinity, ion exchange, size exclusion, hydrophobic interaction chromatography using AKTA FPLC system.
- Proficiency with various analytical protein characterization techniques such as SEC-HPLC, Western blot, SDS-PAGE, Endosafe
- Ability to multi-task and excel in a fast-paced team environment
- Attention to detail, accurate record keeping, and good lab citizenship practices are essential
Other preferred skills:
- Good understanding of gene cloning and construct design
- Experience with protein expression using E. coli, insect and mammalian expression systems is desired
- Experience with other protein characterization technologies (DLS, SEC-MALS, LC/MS, Mass Photometry) would be a strong plus
- Familiar with structure-based design and engineering of proteins (sequence alignment, protein structure analysis using modeling software) is ideal.
The salary range for this position is: $92,820.00 - $120,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.
For additional benefits information, visit:
https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
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The way we see it, the impossible is not impossible. It’s simply what hasn’t been achieved yet. For more than 30 years, we’ve pursued it, chased it down, tackled it for answers and surrounded it for a way in. We have worked tirelessly to bring forward medicines for life-threatening diseases.
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At Gilead, the tangible results of your contributions are evident. Where every individual matters. Where all employees can enhance their skills through ongoing development. And where we start every day with one question: “What’s next?”
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