Scientist - ADC Chemistry

Why Patients Need You
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.
What You Will Achieve
At Pfizer oncology we deliver breakthroughs that change patients' lives with the mission to outdo cancer. The ADC ( Antibody - Drug - Conjugate ) chemistry team plays a vital role in this mission through discovering and advancing novel ADC linker/payload technologies for targeted cancer therapies. We are looking for a highly motivated, creative, and collaborative researcher to join our ADC chemistry team in a lab-based role in Bothell Washington to support novel ADC technology development. The successful candidate will participate in research projects involving the design and synthesis of novel ADC payloads and linkers. Activities may also include coordinating or performing biological assays to understand drug linker and ADC properties .
ROLE RESPONSIBILITIES

• Design and p erform multi-step syntheses of novel ADC payloads, drug linkers, and key intermediates.

• Work independently to d evelop, troubleshoot and optimize synthetic routes, including modular routes for rapid analog generation and efficient scalable routes for early-stage drug candidates.

• Operate a variety of analytical instruments and technologies including HPLC, LC/MS, NMR to enable structural determination and purity assessment.

• Work effectively in both independent and highly collaborative settings.

• Analyze and accurately record data using Electronic Laboratory Notebooks.

• Actively participate in discussions and present results in the form of written reports and oral presentations.

• Adhere to all company safety, scientific record keeping, and compliance requirements.

QUALIFICATIONS

• Master's degree with 4+ years or bachelor's degree with 6+ years industrial experience as a synthetic organic chemist

• Deep understanding of organic functional groups, reaction mechanisms and reactivity.

• Ability to use chemistry and literature/patent searching software to plan and execute synthetic strategies.

• P roven record as a synthetic organic chemist familiar with a wide range of reaction types and having demonstrated multi-step synthesis, purification, and characterization of organic compounds, especially using NMR and mass spectroscopy.

• Strong interpersonal skills and effective written/verbal communication.

• Ability to work effectively in multi-disciplinary teams, learn new skills and proactively solve problems.

Please submit your resume , optional cover letter and 1-2 page research summary
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development